[Association of serum vitamin D and acute renal graft dysfunction].

Abstract

Background: Chronic kidney disease (CKD) is a clinical entity characterized by definitive or non-reversible deterioration of the kidney's architecture and/or its functional status. Renal transplantation is the treatment of choice for CKD. New pharmacological therapies have been investigated with the aim of reducing the risk of renal graft rejection; an example of this is vitamin D. However, international evidence presents mixed results.

Objective: To evaluate the relationship between serum vitamin D levels and the prevalence of acute renal graft dysfunction in renal transplant patients.

Material and methods: A prospective, observational and comparative study was carried out with a population of patients who underwent renal transplantation. The patients were classified into 2 groups: group 1: patients with acute graft dysfunction, and group 2, those without acute graft dysfunction.

Results: A statistically significant relationship was found between acute renal graft dysfunction and serum vitamin D levels (p = 0.003). All other characteristics did not show a statistically significant relationship with acute renal graft dysfunction.

Conclusions: Low 25-hydroxyvitamin D levels showed a statistically significant association with acute renal graft dysfunction.