[Regional mesenteric oxygen saturation during blood transfusion in premature neonates].

Revista medica del Instituto Mexicano del Seguro Social Pub Date : 2025-05-02 DOI:10.5281/zenodo.15178476

González Alma Patricia, Miriam Anaya-Solorzano, Luis Enrique Hernández-Díaz, Estefanía Calderón-Ambriz, Víctor Darío López-Flores, Gloria Patricia Sosa-Bustamante, Carlos Paque-Bautista

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Abstract

Background: Neonatal anemia (NA) in premature newborns (PTNB) is common and transfusion is one of the treatments of choice; however, it has been associated with the development of necrotizing enterocolitis (NEC).

Objective: To compare regional oxygen saturation (rSO2) and fraction of tissue oxygen excretion (FTOE) at baseline, during and at the end of transfusion in PTNBs with anemia.

Material and methods: Prospective, observational, longitudinal, and analytical study. PTNBs of 28-36 weeks of gestational age (WGA) admitted to a Neonatal Intensive Care Unit (NICU) and with transfusion criteria of Canadian Blood Services were included. rSO2 was measured one hour before, during and up to one hour after transfusion.

Results: 20 PTNBs were analyzed, 3 (15%) girls and 17 (85%) boys, aged 33 WGA (IQR 28-36), postnatal age 31 days (IQR 15-50), and weight of 1815 g (IQR 1385-2520). The rSO2 values before, during and after erythrocyte transfusion were 45.5% (IQR 38.25-60.25), 53.3% (IQR 44.25-64.0) and 53.5% (IQR 50.0-64.25), respectively, F = 5.76, p = 0.006, power = 0.83, DF = 2; FTOE values were 0.50 (IQR 0.31-0.56), 0.42 (IQR 0.30-0.50), and 0.39 (IQR 0.27-0.45), respectively, F = 3.53, p = 0.03, power = 0.62, DF = 2.

Conclusion: Mesenteric rSO2 measurements increased and FTOE decreased gradually before, during and after erythrocyte transfusion, without showing correlation with pretransfusion hemoglobin.

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[早产儿输血时肠系膜局部氧饱和度]。

背景：新生儿贫血（NA）在早产新生儿（PTNB）是常见的，输血是治疗的选择之一；然而，它与坏死性小肠结肠炎（NEC）的发展有关。目的：比较ptnb伴贫血患者输血时基线、输血期间和输血结束时的区域氧饱和度（rSO2）和组织氧排泄分数（FTOE）。材料和方法：前瞻性、观察性、纵向和分析性研究。纳入了28-36孕周（WGA）的新生儿重症监护病房（NICU），并符合加拿大血液服务中心的输血标准的ptnb。在输血前1小时、输血中1小时及输血后1小时测量rSO2。结果：共分析20例ptnb，其中女孩3例（15%），男孩17例（85%），年龄33 WGA (IQR 28-36)，出生后31天（IQR 15-50），体重1815 g （IQR 1385-2520）。输血前后rSO2值分别为45.5% （IQR 38.25 ~ 60.25）、53.3% （IQR 44.25 ~ 64.0）、53.5% (IQR 50.0 ~ 64.25), F = 5.76, p = 0.006, power = 0.83, DF = 2；FTOE值分别为0.50 （IQR 0.31 ~ 0.56）、0.42 （IQR 0.30 ~ 0.50）、0.39 (IQR 0.27 ~ 0.45), F = 3.53, p = 0.03, power = 0.62, DF = 2。结论：输血前、输血中、输血后肠系膜rSO2逐渐升高，FTOE逐渐降低，与输血前血红蛋白无相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista medica del Instituto Mexicano del Seguro Social

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