González Alma Patricia, Miriam Anaya-Solorzano, Luis Enrique Hernández-Díaz, Estefanía Calderón-Ambriz, Víctor Darío López-Flores, Gloria Patricia Sosa-Bustamante, Carlos Paque-Bautista
{"title":"[Regional mesenteric oxygen saturation during blood transfusion in premature neonates].","authors":"González Alma Patricia, Miriam Anaya-Solorzano, Luis Enrique Hernández-Díaz, Estefanía Calderón-Ambriz, Víctor Darío López-Flores, Gloria Patricia Sosa-Bustamante, Carlos Paque-Bautista","doi":"10.5281/zenodo.15178476","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Neonatal anemia (NA) in premature newborns (PTNB) is common and transfusion is one of the treatments of choice; however, it has been associated with the development of necrotizing enterocolitis (NEC).</p><p><strong>Objective: </strong>To compare regional oxygen saturation (rSO2) and fraction of tissue oxygen excretion (FTOE) at baseline, during and at the end of transfusion in PTNBs with anemia.</p><p><strong>Material and methods: </strong>Prospective, observational, longitudinal, and analytical study. PTNBs of 28-36 weeks of gestational age (WGA) admitted to a Neonatal Intensive Care Unit (NICU) and with transfusion criteria of Canadian Blood Services were included. rSO2 was measured one hour before, during and up to one hour after transfusion.</p><p><strong>Results: </strong>20 PTNBs were analyzed, 3 (15%) girls and 17 (85%) boys, aged 33 WGA (IQR 28-36), postnatal age 31 days (IQR 15-50), and weight of 1815 g (IQR 1385-2520). The rSO2 values before, during and after erythrocyte transfusion were 45.5% (IQR 38.25-60.25), 53.3% (IQR 44.25-64.0) and 53.5% (IQR 50.0-64.25), respectively, F = 5.76, p = 0.006, power = 0.83, DF = 2; FTOE values were 0.50 (IQR 0.31-0.56), 0.42 (IQR 0.30-0.50), and 0.39 (IQR 0.27-0.45), respectively, F = 3.53, p = 0.03, power = 0.62, DF = 2.</p><p><strong>Conclusion: </strong>Mesenteric rSO2 measurements increased and FTOE decreased gradually before, during and after erythrocyte transfusion, without showing correlation with pretransfusion hemoglobin.</p>","PeriodicalId":94200,"journal":{"name":"Revista medica del Instituto Mexicano del Seguro Social","volume":"63 3","pages":"e6640"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124861/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista medica del Instituto Mexicano del Seguro Social","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5281/zenodo.15178476","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Neonatal anemia (NA) in premature newborns (PTNB) is common and transfusion is one of the treatments of choice; however, it has been associated with the development of necrotizing enterocolitis (NEC).
Objective: To compare regional oxygen saturation (rSO2) and fraction of tissue oxygen excretion (FTOE) at baseline, during and at the end of transfusion in PTNBs with anemia.
Material and methods: Prospective, observational, longitudinal, and analytical study. PTNBs of 28-36 weeks of gestational age (WGA) admitted to a Neonatal Intensive Care Unit (NICU) and with transfusion criteria of Canadian Blood Services were included. rSO2 was measured one hour before, during and up to one hour after transfusion.
Results: 20 PTNBs were analyzed, 3 (15%) girls and 17 (85%) boys, aged 33 WGA (IQR 28-36), postnatal age 31 days (IQR 15-50), and weight of 1815 g (IQR 1385-2520). The rSO2 values before, during and after erythrocyte transfusion were 45.5% (IQR 38.25-60.25), 53.3% (IQR 44.25-64.0) and 53.5% (IQR 50.0-64.25), respectively, F = 5.76, p = 0.006, power = 0.83, DF = 2; FTOE values were 0.50 (IQR 0.31-0.56), 0.42 (IQR 0.30-0.50), and 0.39 (IQR 0.27-0.45), respectively, F = 3.53, p = 0.03, power = 0.62, DF = 2.
Conclusion: Mesenteric rSO2 measurements increased and FTOE decreased gradually before, during and after erythrocyte transfusion, without showing correlation with pretransfusion hemoglobin.