Does Fasting and High-Fatty Diet Effect Ossseointegration: An Experimental Study.

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Nigerian Journal of Clinical Practice Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI:10.4103/njcp.njcp_835_23

C A Kaya, R Guler, M C Yavuz, E C Ozcan, A Bozoglan, S Dundar

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引用次数: 0

Abstract

Background: Hyperlipidemia caused by a high-fat diet (HFD) has many adverse effects on the cardiovascular system, including vascular problems. In addition, a high-fat diet has significant adverse effects on bone health.

Aim: This study aimed to investigate the levels of bone-implant connection in rats subjected to fasting and a high-fatty diet.

Methods: This study utilized a sample size of 28 female Spraque-Dawley rats. The rats were divided into four groups, with 7 rats in each group; the control group on a normal diet (Group 1) (n = 7), the fasted group (Group 2) (n = 7), the high-fatty diet (HFD) group (Group 3) (n = 7), and the fasted and high-fat diet (Group 4) (n = 7). Machined surfaced titanium implants with a diameter of 2.5 mm and a length of 4 mm were placed in the right tibia bones of the subjects. All rats that continued the administered diet for 12 weeks were sacrificed at the end of the experimental period. The implants and the surrounding bone tissue were surgically removed and subjected to biomechanical analysis to assess bone-implant osteintegration.

Results: There was no statistically significant difference in bone-implant osteointegration (P > 0,05) between the rats in the control group and the other three groups.

Conclusion: This study determined that fasting or maintaining a high-fat diet does not adversely affect the bone-implant connection in rats' tibias.

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禁食和高脂肪饮食是否影响骨整合：一项实验研究。

背景：高脂肪饮食（HFD）引起的高脂血症对心血管系统有许多不良影响，包括血管问题。此外，高脂肪饮食对骨骼健康有显著的不利影响。目的：本研究旨在探讨禁食和高脂肪饮食大鼠的骨-种植体连接水平。方法：本研究采用雌性Spraque-Dawley大鼠28只。将大鼠分为4组，每组7只；正常饮食对照组（第1组）（n = 7）、禁食组（第2组）（n = 7）、高脂肪饮食组（第3组）（n = 7）、禁食加高脂肪饮食组（第4组）（n = 7）。将直径为2.5 mm、长度为4 mm的机械表面钛植入受试者的右侧胫骨。所有持续给药12周的大鼠在实验结束时处死。手术切除种植体和周围骨组织，并进行生物力学分析以评估骨-种植体骨整合。结果：对照组大鼠与其他三组大鼠在骨种植体骨融合方面差异无统计学意义（P < 0.05）。结论：本研究确定禁食或维持高脂肪饮食不会对大鼠胫骨的骨-种植体连接产生不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nigerian Journal of Clinical Practice MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

275

审稿时长

4-8 weeks

期刊介绍： The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.