Natural product-based nanotechnological formulations for colorectal cancer treatment.

IF 3.1 4区医学 Q2 PHARMACOLOGY & PHARMACY

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-10-01 Epub Date: 2025-04-25 DOI:10.1007/s00210-025-04175-y

Lanfang Wu, Jiali Wu, Xinyu Wang, Youfa Xu, Zhizhe Lin, Jianming Chen, Xin Wu

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引用次数: 0

Abstract

Colorectal cancer is one of the most common malignancies affecting the gastrointestinal tract. A silent onset often marks it and carries a poor prognosis. Studies have shown that natural products can suppress the growth of colorectal cancer and exert therapeutic effects at the molecular level. However, unfavorable physicochemical properties frequently hinder their clinical application, such as low solubility, limited bioavailability, short half-life, and rapid systemic clearance. As scientific and technological progress continues, increasing attention has been directed toward nanotechnology-based approaches. Techniques involving nanoparticles, liposomes, and micelles are being explored to improve drug delivery. These advancements provide a promising foundation for overcoming the limitations associated with natural products. This review systematically examines the application of nano-formulations for natural ingredients to offer meaningful insights into their. potential use in treating colorectal cancer.

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用于结直肠癌治疗的天然产品纳米技术配方。

结直肠癌是影响胃肠道最常见的恶性肿瘤之一。无症状发作通常是该病的标志，预后很差。研究表明，天然产物可以抑制结直肠癌的生长，并在分子水平上发挥治疗作用。然而，不利的物理化学性质经常阻碍其临床应用，如低溶解度，有限的生物利用度，半衰期短，快速全身清除。随着科学技术的不断进步，人们越来越关注基于纳米技术的方法。人们正在探索纳米颗粒、脂质体和胶束等技术来改善药物输送。这些进步为克服与天然产物相关的局限性提供了有希望的基础。本综述系统地研究了天然成分的纳米配方的应用，以提供有意义的见解。治疗结直肠癌的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Naunyn-Schmiedeberg's archives of pharmacology 医学-药学

CiteScore

6.20

自引率

5.60%

发文量

142

审稿时长

4-8 weeks

期刊介绍： Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.