Exploration of IgE Specific to Staphylococcal Serine Protease-Like Protein A as a Phenotypic Marker in Late-Onset Asthma.

IF 4.6 2区医学 Q1 RESPIRATORY SYSTEM

Lung Pub Date : 2025-04-18 DOI:10.1007/s00408-025-00810-w

Ha-Kyeong Won, Jiwon Lee, Kyung Eun Park, Jun-Pyo Choi, Woo-Jung Song

{"title":"Exploration of IgE Specific to Staphylococcal Serine Protease-Like Protein A as a Phenotypic Marker in Late-Onset Asthma.","authors":"Ha-Kyeong Won, Jiwon Lee, Kyung Eun Park, Jun-Pyo Choi, Woo-Jung Song","doi":"10.1007/s00408-025-00810-w","DOIUrl":null,"url":null,"abstract":"Purpose: Staphylococcus aureus (SA) secretes pro-allergic molecules, including staphylococcal enterotoxins (SEs) and serine protease-like proteins (Spls). While IgE sensitization to SE has been relatively well documented in relation to severe eosinophilic late-onset asthma, the clinical implications of IgE sensitization to Spls remain unclear. We explored the clinical relevance of Spl-IgE in late-onset asthmatics.Methods: Adults with late-onset asthma (onset age ≥ 40 years) were prospectively enrolled. Demographic and clinical characteristics were assessed, and serum levels of total IgE, SE-IgE, and SplA-IgE were measured. Nasal swabs were obtained to assess SA colonization.Results: Among 109 participants, SplA-IgE levels were significantly associated with blood eosinophilia, total IgE, SE-IgE sensitization, and male sex, but not with SA colonization, asthma severity, or lung function.Conclusion: Sensitization to SplA-IgE may indicate a type 2 inflammatory phenotype, but its role in asthma warrants further investigation.","PeriodicalId":18163,"journal":{"name":"Lung","volume":"203 1","pages":"56"},"PeriodicalIF":4.6000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lung","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00408-025-00810-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Staphylococcus aureus (SA) secretes pro-allergic molecules, including staphylococcal enterotoxins (SEs) and serine protease-like proteins (Spls). While IgE sensitization to SE has been relatively well documented in relation to severe eosinophilic late-onset asthma, the clinical implications of IgE sensitization to Spls remain unclear. We explored the clinical relevance of Spl-IgE in late-onset asthmatics.

Methods: Adults with late-onset asthma (onset age ≥ 40 years) were prospectively enrolled. Demographic and clinical characteristics were assessed, and serum levels of total IgE, SE-IgE, and SplA-IgE were measured. Nasal swabs were obtained to assess SA colonization.

Results: Among 109 participants, SplA-IgE levels were significantly associated with blood eosinophilia, total IgE, SE-IgE sensitization, and male sex, but not with SA colonization, asthma severity, or lung function.

Conclusion: Sensitization to SplA-IgE may indicate a type 2 inflammatory phenotype, but its role in asthma warrants further investigation.

查看原文本刊更多论文

探索葡萄球菌丝氨酸蛋白酶样蛋白A特异性IgE作为晚发型哮喘表型标记。

目的：金黄色葡萄球菌（Staphylococcus aureus， SA）分泌促过敏分子，包括葡萄球菌肠毒素（Staphylococcus enterotoxins, SEs）和丝氨酸蛋白酶样蛋白（serine protease-like proteins, Spls）。虽然对SE的IgE致敏与严重嗜酸性粒细胞迟发性哮喘的关系已得到较好的记录，但对Spls的IgE致敏的临床意义仍不清楚。我们探讨了spll - ige在迟发性哮喘患者中的临床意义。方法：前瞻性纳入迟发性哮喘成人（发病年龄≥40岁）。评估人口统计学和临床特征，测定血清总IgE、SE-IgE和SplA-IgE水平。获得鼻拭子以评估SA定植。结果：在109名参与者中，SplA-IgE水平与血嗜酸性粒细胞、总IgE、SE-IgE致敏和男性性别显著相关，但与SA定植、哮喘严重程度或肺功能无关。结论：SplA-IgE致敏可能提示2型炎症表型，但其在哮喘中的作用有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Lung 医学-呼吸系统

CiteScore

9.10

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.