The Istanbul Consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment† ‡

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Reproductive biomedicine online Pub Date : 2025-06-01 DOI:10.1016/j.rbmo.2025.104955

The Working Group on the update of the ESHRE/ALPHA Istanbul Consensus,, Giovanni Coticchio , Aisling Ahlström , Gemma Arroyo , Basak Balaban , Alison Campbell , Maria José De Los Santos , Thomas Ebner , David K. Gardner , Borut Kovačič , Kersti Lundin , M. Cristina Magli , Saria Mcheik , Dean E. Morbeck , Laura Rienzi , Ioannis Sfontouris , Nathalie Vermeulen , Mina Alikani

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引用次数: 0

Abstract

This European Society of Human Reproduction and Embryology (ESHRE)/Alpha Scientists in Reproductive Medicine (ALPHA) consensus document provides several novel recommendations to assess oocyte and embryo morphology and rank embryos for transfer. A previous ALPHA/ESHRE consensus on oocyte and embryo morphological assessment was published in 2011. After more than a decade, and the integration of time-lapse technology into embryo culture and assessment, a thorough review and update was needed. A working group consisting of ALPHA members and ESHRE Special interest group of Embryology members formulated recommendations on oocyte and embryo assessment. The working group included 17 internationally recognized experts with extensive experience in clinical embryology. Seven members represented ALPHA and eight members represented ESHRE, along with two methodological experts from the ESHRE central office. Based on a systematic literature search and discussion of existing evidence, the recommendations of the Istanbul Consensus (2011) were reassessed and, where appropriate, updated based on consensus within the working group. A stakeholder review was organized after the updated draft was finalized. The final version was approved by the working group, the ALPHA Executive Committee and the ESHRE Executive Committee. This updated consensus paper provides 20 recommendations focused on the timeline of preimplantation developmental events and morphological criteria for oocyte, zygote and embryo assessment. Based on the duration of embryo culture, recommendations are given on the frequency and timing of assessments to ensure consistency and effectiveness. Several criteria relevant to oocyte and embryo morphology have not been well studied, leading to either a recommendation against their use for grading or for their use in ranking rather than grading. Future updates may require further revision of these recommendations. This document provides embryologists with advice on best practices when assessing oocyte and embryo quality based on the most recent evidence.

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伊斯坦布尔共识更新：修订ESHRE/ALPHA共识对卵母细胞和胚胎的静态和动态形态评估†‡。

这份欧洲人类生殖与胚胎学会(ESHRE)/Alpha生殖医学科学家（Alpha）共识文件提供了一些新的建议来评估卵母细胞和胚胎形态并对胚胎进行移植排序。之前关于卵母细胞和胚胎形态评估的ALPHA/ESHRE共识发表于2011年。在将延时技术应用于胚胎培养和评估的十多年后，需要对其进行彻底的审查和更新。由ALPHA成员和ESHRE胚胎学特别兴趣小组成员组成的工作组制定了关于卵母细胞和胚胎评估的建议。该工作组包括17位在临床胚胎学方面具有丰富经验的国际公认专家。ALPHA的七名成员和ESHRE的八名成员，以及ESHRE中央办公室的两名方法专家。基于系统的文献检索和对现有证据的讨论，对伊斯坦布尔共识（2011年）的建议进行了重新评估，并酌情根据工作组的共识进行了更新。在更新的草案定稿后，组织了一次利益相关者审查。最终版本由工作组、ALPHA执行委员会和ESHRE执行委员会批准。这篇更新的共识论文提供了20条建议，重点是着床前发育事件的时间表和卵母细胞、受精卵和胚胎评估的形态学标准。根据胚胎培养的持续时间，对评估的频率和时间提出建议，以确保一致性和有效性。与卵母细胞和胚胎形态学相关的几个标准尚未得到很好的研究，导致要么建议不使用它们进行分级，要么建议使用它们进行排名而不是分级。将来的更新可能需要进一步修订这些建议。本文件为胚胎学家提供了基于最新证据评估卵母细胞和胚胎质量的最佳实践建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.