Histomorphometric Analysis of the Human Umbilical Cord and Its Vessels in Pregnant Women with Anemia: A Case-Control Study.

IF 0.7 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Nigerian Journal of Clinical Practice Pub Date : 2025-03-01 Epub Date: 2025-04-11 DOI:10.4103/njcp.njcp_648_24
I Ahmed, A Elmugabil, M M Salih, L E Ali, A A Siniyeh, E H Khalifa, S M Hanafy, I Adam
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引用次数: 0

Abstract

Background: Anemia during pregnancy is a significant public health concern as it is associated with adverse maternal and fetal consequences.

Aim: To assess the histomorphometric changes in the umbilical cord as an indicator of maternal physiological dysfunction and to evaluate the impact of maternal anemia on fetal development.

Methods: A case-control study was conducted to explore the histomorphometric changes in UC and its vessels in women with anemia in Central Sudan. The following parameters were studied using the ImageJ software: vessel area (VA), wall area (WA), lumen area (LA), mean wall thickness boundary (MWTB), mean wall thickness skeleton (MWTS), and external diameter skeleton (EDS).

Results: UCs were studied in 73 women with anemia and 102 women without anemia. Only one woman had severe anemia (hemoglobin level, <7 g/dl). Maternal age, parity, and gestational age showed no significant differences between women with and without anemia. However, the median (interquartile range) birth weight was significantly lower in women with anemia than in those without anemia [3.29 (2.91‒3.58) g vs 3.42 (3.09‒3.77) g, P = 0.043]. None of the investigated variables (VVA, WA, LA), MWTB, MWTS, and EDS) did not differ between women with and without anemia. No significant correlations were found between maternal hemoglobin levels and UC parameters.

Conclusion: The current study showed no difference in UC parameters between women with and without anemia. The nonsevere form of anemia may explain the results of this study. Therefore, further research is required in this regard.

Data access statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request. Due to ethical and privacy concerns, some data may be restricted in accordance with institutional and regulatory guidelines.

贫血孕妇脐带及其血管的组织形态学分析:一项病例对照研究。
背景:妊娠期贫血是一个重要的公共卫生问题,因为它与母体和胎儿的不良后果有关。目的:探讨脐带组织形态学变化作为母体生理功能障碍的指标,探讨母体贫血对胎儿发育的影响。方法:通过病例对照研究,探讨苏丹中部贫血妇女UC及其血管的组织形态学变化。使用ImageJ软件研究以下参数:血管面积(VA)、壁面积(WA)、管腔面积(LA)、平均壁厚边界(MWTB)、平均壁厚骨架(MWTS)和外径骨架(EDS)。结果:对73例贫血妇女和102例无贫血妇女进行了UCs研究。结论:目前的研究显示,有和没有贫血的女性在UC参数上没有差异。非严重形式的贫血可以解释这项研究的结果。因此,这方面还需要进一步的研究。数据访问声明:支持本研究结果的数据可根据通讯作者的合理要求提供。出于道德和隐私方面的考虑,某些数据可能会根据机构和监管准则受到限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nigerian Journal of Clinical Practice
Nigerian Journal of Clinical Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
275
审稿时长
4-8 weeks
期刊介绍: The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.
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