Magnitude of Diabetes Mellitus and Associated Factors Among HIV-Infected Individuals on Follow-Up Care at Kuyu General Hospital, North Shoa, Oromia, Ethiopia.

IF 2.3 Q3 NUTRITION & DIETETICS
Journal of Nutrition and Metabolism Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.1155/jnme/7001308
Sahilu Tesfaye Weyessa, Eyoel Berhan Mekonen, Tesfalem Teshome Tessema
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引用次数: 0

Abstract

Background: Antiretroviral therapy (ART) drugs improve life expectancy and reduce mortality. However, due to treatment-related metabolic complications, they are now developing comorbidities. In Ethiopia, there are a few reports of diabetes mellitus (DM)-human immunodeficiency virus (HIV) comorbidity. This study explores the magnitude of DM and associated factors among HIV-infected individuals on follow-up care at Kuyu General Hospital, Ethiopia. Materials and Methods: A cross-sectional study design was conducted at Kuyu General Hospital from March 10, 2021-April, 2021. Adults with HIV-positive (aged ≥ 18 years) who were on ART were included. Systematic random sampling was used to select 294 HIV-positive adults who attended regular follow-up at the ART clinic. Descriptive analysis was conducted and reported in frequency and percentage. Both bivariable and multivariable analyses were computed. Variables with p < 0.25 in bivariable analysis were inserted into a multivariable logistic regression model to control possible confounders. The p value < 0.05 at a 95% confidence interval was considered as statistically significant. Results: The age of the HIV-infected individuals enrolled ranged from 18 to 67 years with the mean age of 39.08 (SD = ±11.5) years. DM was detected in 21 (7.14%; 95% CI: 4.1-10.2) patients on medication whereas fasting plasma glucose between 111-125 mg/dL was 39 (13.3%; 95% CI: 9.5-17.3). The maximum (12.6%) of DM patients were aged 45 years and above. In the multivariable analysis, hypertension (AOR = 3.4, 95% CI: 1.1-10.8), elevated total cholesterol (AOR = 4.3, 95% CI: 1.2-15.6), aged 45 years and above (AOR = 3.9, 95% CI: 1.15-13.6), and duration of HIV (AOR = 4.7, 95% CI: 1.3-16.9) were significantly associated with DM. Conclusions: In this study, the magnitude of DM among HIV-infected adults on ART follow-up was higher than the prevalence of DM in general populations. Older age, hypertension, increased total cholesterol, and duration of HIV were associated with a higher prevalence of DM. It is better for care providers assigned at ART clinics to detect DM, particularly after initiation of ART routinely, which may help to provide integrated care for comorbid patients.

埃塞俄比亚奥罗米亚北部Shoa库尤总医院艾滋病病毒感染者糖尿病程度及相关因素随访
背景:抗逆转录病毒治疗(ART)药物可提高预期寿命并降低死亡率。然而,由于治疗相关的代谢并发症,他们现在正在发展合并症。在埃塞俄比亚,有一些关于糖尿病(DM)-人类免疫缺陷病毒(HIV)合并症的报道。本研究探讨了在埃塞俄比亚库尤总医院接受随访治疗的艾滋病毒感染者中糖尿病的程度及其相关因素。材料与方法:横断面研究设计于2021年3月10日- 2021年4月在库峪总医院进行。纳入接受抗逆转录病毒治疗的成人hiv阳性(年龄≥18岁)。采用系统随机抽样的方法,选取294名在ART诊所定期随访的hiv阳性成人。进行描述性分析,并报告频率和百分比。计算双变量和多变量分析。将双变量分析中p < 0.25的变量插入到多变量logistic回归模型中,以控制可能的混杂因素。p值在95%置信区间< 0.05被认为具有统计学意义。结果:纳入的hiv感染者年龄在18 ~ 67岁之间,平均年龄39.08岁(SD =±11.5)岁。21例(7.14%)检出DM;95% CI: 4.1-10.2),而空腹血糖在111-125 mg/dL之间的患者为39 (13.3%;95% ci: 9.5-17.3)。45岁及以上的糖尿病患者最多(12.6%)。在多变量分析中,高血压(AOR = 3.4, 95% CI: 1.1-10.8)、总胆固醇升高(AOR = 4.3, 95% CI: 1.2-15.6)、45岁及以上(AOR = 3.9, 95% CI: 1.15-13.6)和HIV持续时间(AOR = 4.7, 95% CI: 1.3-16.9)与糖尿病显著相关。结论:本研究中,接受ART随访的HIV感染成人中糖尿病的严重程度高于普通人群中糖尿病的患病率。老年、高血压、总胆固醇升高和HIV持续时间与糖尿病的高患病率相关。ART诊所的医护人员最好能检测到糖尿病,特别是在常规开始ART治疗后,这可能有助于为合并症患者提供综合护理。
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来源期刊
Journal of Nutrition and Metabolism
Journal of Nutrition and Metabolism NUTRITION & DIETETICS-
CiteScore
5.40
自引率
0.00%
发文量
49
审稿时长
17 weeks
期刊介绍: Journal of Nutrition and Metabolism is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering the broad and multidisciplinary field of human nutrition and metabolism. The journal welcomes submissions on studies related to obesity, diabetes, metabolic syndrome, molecular and cellular biology of nutrients, foods and dietary supplements, as well as macro- and micronutrients including vitamins and minerals.
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