Relationship Between Hemoglobin A1c and Fecal Incontinence in a Nationwide Cohort Study.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

Neurogastroenterology and Motility Pub Date : 2025-07-01 Epub Date: 2025-04-24 DOI:10.1111/nmo.70026

Sanskriti Varma, Sonia Bhatia, Aditya Ashok, Braden Kuo, Kyle Staller

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引用次数: 0

Abstract

Introduction: Gastrointestinal manifestations of diabetes include a variety of symptoms, including fecal incontinence (FI). We investigated the relationship between hemoglobin A1c and FI among US adults in a large, population-based survey.

Methods: We identified adults (≥ 20 years) who completed the bowel health questionnaire and had A1c data in the National Health and Nutrition Examination Survey from 2005 to 2010 (N = 13,787). FI was defined as any involuntary loss of mucus, liquid, or solid stool during the last 30 days. Adjusted odds ratios (aORs) for FI were estimated in a multivariable logistic model according to A1c. Subgroup analyses examined relevant characteristics.

Results: We identified 1283 (9.3%) adults with FI. A1c was associated with a 26% increase in the odds of FI (crude OR 1.26, 95% CI 1.20-1.33), which persisted after stepwise adjustment for age, demographic factors, and comorbidities (aOR 1.09, 95% CI 1.01-1.17). In subgroup analyses, A1c was associated with FI in diabetes (aOR 1.13, 95% CI 1.01-1.26), women (aOR 1.15, 95% CI 1.02-1.3), those < 65 years of age (aOR 1.17, 95% CI 1.09-1.25), overweight/obesity (aOR 1.1, 95% CI 1.02-1.20), non-white (aOR 1.1, 95% CI 1.01-1.20), and those with solid stool FI (aOR 1.17, 95% CI 1.04-1.32).

Conclusion: Increasing A1c was associated with an increased odds of FI. Our study provides insights into subgroups of patients who may benefit from interventions aimed at glucose control to reduce this risk of FI.

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一项全国性队列研究中A1c与大便失禁的关系

导言：糖尿病的胃肠道表现包括多种症状，包括大便失禁（FI）。我们通过一项基于人群的大型调查研究了美国成年人中血红蛋白A1c与FI之间的关系。方法：在2005年至2010年的全国健康与营养检查调查中，我们选取了完成肠道健康问卷并有A1c数据的成年人（≥20岁）（N = 13,787）。FI定义为在过去30天内任何粘液、液体或固体粪便的不自主流失。根据A1c在多变量logistic模型中估计FI的调整优势比（aORs）。亚组分析检查了相关特征。结果：我们确定了1283例（9.3%）成人FI。A1c与FI发生率增加26%相关（粗OR 1.26, 95% CI 1.20-1.33），在对年龄、人口统计学因素和合并症进行逐步调整后，这种情况仍然存在（aOR 1.09, 95% CI 1.01-1.17）。在亚组分析中，糖尿病患者A1c与FI相关（aOR为1.13,95% CI 1.01-1.26），女性患者A1c与FI相关（aOR为1.15,95% CI 1.02-1.3），结论：A1c升高与FI发生率增加相关。我们的研究为可能受益于血糖控制干预以降低FI风险的患者亚组提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogastroenterology and Motility 医学-临床神经学

CiteScore

7.80

自引率

8.60%

发文量

178

审稿时长

3-6 weeks

期刊介绍： Neurogastroenterology & Motility (NMO) is the official Journal of the European Society of Neurogastroenterology & Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS). It is edited by James Galligan, Albert Bredenoord, and Stephen Vanner. The editorial and peer review process is independent of the societies affiliated to the journal and publisher: Neither the ANMS, the ESNM or the Publisher have editorial decision-making power. Whenever these are relevant to the content being considered or published, the editors, journal management committee and editorial board declare their interests and affiliations.