COVID-19 Challenges in Autoimmune Hepatitis Management: A Successful Outcome With Intravenous Immune Globulin (IVIg).

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

Case Reports in Gastrointestinal Medicine Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI:10.1155/crgm/4446896

Amirali Mashhadiagha, Parnian Khalili, Maryam Ataollahi, Fereshteh Karbasian, Ali Arman, Bita Geramizadeh

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Abstract

Background: Several autoimmune diseases, such as autoimmune hepatitis (AIH), can arise or become decompensated following COVID-19 infection or vaccination; however, there is a lack of data regarding the management of concurrent COVID-19 infection and autoimmune diseases. Case Summary: In this paper, we present a case of a 9-year-old boy with yellowish discoloration of the skin and sclera, abnormal liver function test, followed by positive qRT-PCR for SARS-CoV-2 and progressive bicytopenia. After a lack of response to corticosteroids, intravenous immune globulin (IVIg) was administrated and a decline in liver enzymes, total bilirubin, and direct bilirubin was observed. Result and Discussion: This case illustrates how IVIg significantly improved the AIH symptoms in the patient with positive qRT-PCR for the SARS-CoV-2 test. We hope our report encourages further research on therapeutic approaches for AIH concomitant with COVID-19.

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自身免疫性肝炎管理中的COVID-19挑战：静脉注射免疫球蛋白（IVIg）的成功结果。

背景：几种自身免疫性疾病，如自身免疫性肝炎（AIH），可在COVID-19感染或疫苗接种后出现或失代偿；然而，缺乏关于同时感染COVID-19和自身免疫性疾病的管理数据。病例总结：本文报告1例9岁男童，皮肤和巩膜黄变，肝功能检查异常，随后出现SARS-CoV-2 qRT-PCR阳性和进行性双氧体减少症。在对皮质类固醇缺乏反应后，静脉注射免疫球蛋白（IVIg），观察到肝酶、总胆红素和直接胆红素的下降。结果与讨论：本病例说明了IVIg如何显著改善了SARS-CoV-2检测qRT-PCR阳性患者的AIH症状。我们希望我们的报告能够鼓励对COVID-19合并AIH治疗方法的进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Case Reports in Gastrointestinal Medicine GASTROENTEROLOGY & HEPATOLOGY-

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审稿时长

14 weeks