Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis.

IF 5.9 2区医学 Q1 NEUROSCIENCES

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI:10.1007/s12264-025-01370-y

Shasha Zhang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Buwei Shao, He Li, Lei Xu, Xiaoqiong Ding, Renjie Chai

引用次数: 0

Abstract

Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.

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获得性感音神经性听力损失的靶向程序性细胞死亡：铁下垂、坏死性下垂和焦下垂。

感音神经性听力损失（SNHL）是最常见的听力损失形式，主要由耳蜗毛细胞和螺旋神经节神经元的损伤或丧失引起。许多环境和生理因素已被证明可导致获得性SNHL，如耳毒性药物、噪音暴露、衰老、感染和疾病。一些程序性细胞死亡（PCD）途径已被报道参与SNHL，特别是一些新的PCD途径最近才被报道，如铁下垂、坏死下垂和焦下垂。本文总结了这些PCD通路及其在SNHL中的作用和机制，旨在通过靶向这些PCD通路为SNHL的治疗提供新的见解和潜在的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience bulletin NEUROSCIENCES-

CiteScore

7.20

自引率

16.10%

发文量

163

审稿时长

6-12 weeks

期刊介绍： Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.