A Comparative Study of Radical Radiotherapy in Very Elderly and Non-Very Elderly Patients With Malignant Tumour Using Pairwise Matching

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Medical Imaging and Radiation Oncology Pub Date : 2025-04-29 DOI:10.1111/1754-9485.13863

Hidekazu Tanaka, Kazushi Ueda, Akane Hironaka, Chika Nakabe, Taiki Ono, Yuki Manabe, Miki Kajima, Koya Fujimoto, Takehiro Shiinoki

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Abstract

Introduction

This study aimed to compare the outcomes and complications following radical radiotherapy between very elderly patients aged ≥ 90 years and non-very elderly patients using pairwise matching analysis.

Methods

Data of patients who underwent radical radiotherapy at our hospital between January 2013 and March 2024 and those who were aged ≥ 90 years at the start of radical radiotherapy were extracted. Data of control patients were extracted by pairwise matching from patients aged < 90 years who underwent radical radiotherapy during the same period. Pairwise matching was performed using the following criteria: (i) cancer type, (ii) TNM classification, (iii) histological type, (iv) concurrent chemotherapy, (v) prescribed biological effective dose, (vi) performance status, (vii) sex and (viii) ability to walk. The local control (LC), cancer-specific survival (CSS) and overall survival (OS) rates were calculated from the date of completion of radiotherapy.

Results

Forty patients from each group were analysed. There were no significant differences in LC, CSS or OS rates between the two groups. The completion rate of radiotherapy and the incidence rate of adverse events were not significantly different between the two groups.

Conclusion

In this study, there was no difference in the outcomes of radiotherapy between very elderly and non-very elderly patients. Our findings may aid clinicians in the treatment of nonagenarian patients.

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两两配对根治性放疗治疗高龄与非高龄恶性肿瘤患者的比较研究。

本研究旨在采用两两配对分析的方法，比较≥90岁高龄高龄患者和非高龄患者根治性放疗后的预后和并发症。方法：选取2013年1月至2024年3月在我院接受根治性放疗的患者及放疗开始时年龄≥90岁的患者资料。对照组从老年患者中两两配对提取数据。结果：每组各分析40例患者。两组间LC、CSS和OS率无显著差异。两组放疗完成率及不良事件发生率无显著差异。结论：本研究中，高龄和非高龄患者的放疗效果无差异。我们的发现可能有助于临床医生治疗老年患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Imaging and Radiation Oncology 医学-核医学

CiteScore

3.30

自引率

6.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Medical Imaging and Radiation Oncology (formerly Australasian Radiology) is the official journal of The Royal Australian and New Zealand College of Radiologists, publishing articles of scientific excellence in radiology and radiation oncology. Manuscripts are judged on the basis of their contribution of original data and ideas or interpretation. All articles are peer reviewed.