Can Provence Flora Offer Effective Alternatives to Widely Used Medicinal Plants? A Comparative Study of Antioxidant Activity and Chemical Composition Using Molecular Networking.

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2025-05-07 DOI:10.3390/molecules30092072

Clémentine Achard-Baccati, Elnur Garayev, Charifat Saïd Hassane, Célia Breaud, Eldar Garaev, Myriam Bertolotti, Fathi Mabrouki, Sok-Siya Bun-Llopet, Béatrice Baghdikian

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引用次数: 0

Abstract

This study compares the antioxidant properties and phytochemical profiles of three pairs of widely used medicinal plant species to their counterparts from Provence, France: Arnica montana with Pentanema montanum (formerly known as Inula montana), Helichrysum italicum with Helichrysum stoechas, and Satureja hortensis with Satureja montana. Phytochemical composition has been investigated using UHPLC-HRMS/MS and molecular networking, revealing chemical profiles dominated by phenylpropanoids and flavonoids, with lignans, sesquiterpene lactones, or polyketides aside. Well-plate DPPH/ABTS assays were used to evaluate the antioxidant activity of extracts, and post-column assays were used to identify antioxidant compounds. The three Provence species demonstrated comparable or superior antioxidant activities to their counterparts, primarily attributed to phenolic compounds such as mono- and di-caffeoylquinic acids, quercetagetin-7-O-glucoside, and myricetin acetylhexoside. These findings show the potential of Provence species to be substituted for some overharvested medicinal plants. This research supports biodiversity conservation while promoting the integration of these local species into pharmaceutical, nutraceutical, cosmetic, and food industries.

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普罗旺斯植物群能提供广泛使用的药用植物的有效替代品吗？基于分子网络的抗氧化活性与化学成分比较研究。

摘要本研究比较了法国普罗旺斯地区3对常用药用植物的抗氧化性能和植物化学特征，分别是山金车（Arnica montanum）与五芒花（Pentanema montanum）、意大利蜡菊（helichryum stoechas）与蜡菊（Satureja montana）。利用UHPLC-HRMS/MS和分子网络对植物化学成分进行了研究，揭示了以苯丙素和类黄酮为主的化学特征，以及木脂素、倍半萜内酯或聚酮。采用孔板DPPH/ABTS法评价提取物的抗氧化活性，柱后法鉴定抗氧化成分。这三种普罗旺斯物种表现出与同类相当或更好的抗氧化活性，主要归因于酚类化合物，如单和二咖啡酰奎宁酸、槲皮素-7- o-葡萄糖苷和杨梅素乙酰己糖。这些发现显示了普罗旺斯物种替代某些过度采伐药用植物的潜力。这项研究支持生物多样性保护，同时促进这些当地物种融入制药、营养、化妆品和食品工业。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.