Caoimhe McGarvey, Kate Doyle, Adam Roche, David Mockler, Silvin Knight, Rose Anne Kenny, Donal J Sexton
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引用次数: 0
Abstract
Background: The prevalence of Chronic Kidney Disease (CKD) is rising rapidly due to population ageing, with significant consequences for morbidity and mortality. The use of effective, predictive biomarkers would enable early introduction of targeted, proactive management of kidney disease.
Aim: The aim of this review is to summarise all available studies investigating the association of neurocardiovascular, inflammatory and epigenetic biomarkers with kidney function and their ability to predict CKD incidence or progression.
Design: Systematic review and meta-analysis.
Methods: Systematic searches were conducted in Scopus, Embase, MEDLINE and CINAHL covering available literature until November 29, 2023. Studies assessing the relationship between named biomarkers and kidney outcomes in adults were included. Title, abstract and full text screening involved 2 independent reviewers using Covidence software. Data extraction and quality assessment, using the Newcastle-Ottawa scale (NOS), were completed by two reviewers. Systematic narrative analysis was performed for all biomarkers, and meta-analysis was conducted for studies reporting odds or hazard ratios.
Results: Sixty-eight observational studies were included. Several biomarkers showed significant association with kidney function but significant independent associations with CKD incidence and progression were limited. Results from the meta-analysis: heart rate variability and CKD progression: pooled hazard ratio 1.75 (1.25-2.45), arterial stiffness and kidney function and CKD incidence: pooled odds ratios 1.08 (1.03-1.13) and 1.14 (1.01-1.29).
Conclusions: Further longitudinal research focussing on the outcomes of CKD incidence and progression is required. The use of physiological and molecular biomarkers has the potential to improve the management and prognostication of CKD.
期刊介绍：
QJM, a renowned and reputable general medical journal, has been a prominent source of knowledge in the field of internal medicine. With a steadfast commitment to advancing medical science and practice, it features a selection of rigorously reviewed articles.
Released on a monthly basis, QJM encompasses a wide range of article types. These include original papers that contribute innovative research, editorials that offer expert opinions, and reviews that provide comprehensive analyses of specific topics. The journal also presents commentary papers aimed at initiating discussions on controversial subjects and allocates a dedicated section for reader correspondence.
In summary, QJM's reputable standing stems from its enduring presence in the medical community, consistent publication schedule, and diverse range of content designed to inform and engage readers.
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