New phenazines from Taibai mountain-derived Streptomyces xanthophaeus A54.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-08 DOI:10.1080/14786419.2025.2502141

Lukuan Hou, Xue Yang, Shuyao Wang, Wenli Li

引用次数: 0

Abstract

Four phenazineswere isolated from the Taibai mountain-derived Streptomyces xanthophaeus A54, among which Taibphenazine A (1) and Taibphenazine B (2) are new compounds. Comprehensive spectroscopic analyses, including HRESIMS, NMR, ECD calculations, and optical rotation value, were employed to elucidate the structures of these compounds. Taibphenazine B showed considerable anti-influenza A virus activity (IC₅₀=27.07 μM), which was similar to the positive control ribavirin (IC₅₀=24.20 μM).

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太白山源黄嘌呤链霉菌A54中的新苯那嗪类化合物。

从太白山源链霉菌xanthophaeus A54中分离得到4个非那嗪类化合物，其中Taibphenazine A(1)和Taibphenazine B(2)为新化合物。综合光谱分析，包括hresms， NMR， ECD计算和旋光度值，阐明了这些化合物的结构。Taibphenazine B具有较强的抗甲型流感病毒活性（IC50=27.07 μM），与阳性对照利巴韦林（IC50=24.20 μM）相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.