Highlighted gene expression alteration in human pancreatic isolated islets in patients with type 2 diabetes.

IF 1.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2025-04-23 eCollection Date: 2025-06-01 DOI:10.1007/s40200-025-01611-x

Vahid Mansouri, Babak Arjmand, Mohammad Rostami Nejad, Zahra Razzaghi, Mostafa Rezaei-Tavirani, Farideh Razi, Fatemeh Bandarian, Reza M Robati, Mitra Rezaei, Fatemeh Daneshimehr

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引用次数: 0

Abstract

Objectives: Type 2 diabetes is a complex disease characterized by progressive β-cell failure. The primary mechanism underlying this failure is the progressive loss of pancreatic β-cell function. The aim of this study is to identify the key gene expression changes in human pancreatic isolated islets of patients with type 2 diabetes.

Methods: We extracted gene expression data in human pancreatic isolated islets of patients with type 2 diabetes and healthy controls from Gene Expression Omnibus (GEO) and analyzed it using GEO2R program. We then assessed the significant differentially expressed genes (DEGs) using protein-protein interaction (PPI) network analysis. The critical genes were enriched via gene ontology and discussed.

Results: Among the 93 significant DEGs, five critical genes including ITGB2, APOE, BIRC5, GABRA2, and IL1B were emerged as key players in type 2 diabetes. Notably, "Alzheimer disease, type 4" was identified as a major class of biological terms altered in type 2 diabetes.

Conclusions: Our findings suggest that the introduced critical genes are potential targets for controlling type 2 diabetes. Furthermore, the crucial role of APOE as a link between type 2 diabetes and Alzheimer's disease or other cognitive disorders was confirmed.

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2型糖尿病患者胰岛基因表达改变

目的：2型糖尿病是一种以进行性β细胞衰竭为特征的复杂疾病。这种失败的主要机制是胰腺β细胞功能的逐渐丧失。本研究的目的是确定2型糖尿病患者胰腺离体胰岛的关键基因表达变化。方法：从基因表达图谱（gene expression Omnibus， GEO）中提取2型糖尿病患者和健康人胰腺离体胰岛的基因表达数据，并使用GEO2R程序进行分析。然后，我们使用蛋白-蛋白相互作用（PPI）网络分析评估显著差异表达基因（DEGs）。通过基因本体对关键基因进行富集和讨论。结果：在93个显著deg中，ITGB2、APOE、BIRC5、GABRA2和IL1B等5个关键基因在2型糖尿病中发挥了关键作用。值得注意的是，“阿尔茨海默病，4型”被确定为2型糖尿病改变的主要生物学术语。结论：我们的研究结果表明，引入的关键基因是控制2型糖尿病的潜在靶点。此外，APOE在2型糖尿病和阿尔茨海默病或其他认知障碍之间起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.