M J Mol, H Bouchiba, A S Aelvoet, F Bennebroek Evertsz, F A M Duijkers, J G Karstensen, B A J Bastiaansen, E Dekker, E M A Bleiker
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引用次数: 0
Abstract
Objective: Familial adenomatous polyposis (FAP) is a hereditary disposition causing a nearly 100% risk of developing colorectal cancer without treatment. Therefore lifelong endoscopic surveillance and prophylactic colectomy, generally before the age of 30, are offered. Children of genetically confirmed FAP-patients have a 50% risk of inheriting the disease. It is a challenge to cope with the burden of FAP. The aim of this systematic review was to study the literature on the presence of mental issues, including anxiety, depression, distress, intellectual disability, and symptoms in the autism spectrum in FAP-patients.
Methods: A search was performed in PubMed, EMBASE and Cochrane Library to retrieve English studies on mental health and FAP from inception to May 2024.
Results: Of the 2045 identified papers, 35 met our criteria. Most papers did not show increased levels in mean scores of distress, anxiety or depression. However, subgroups with high levels of distress, anxiety and depression were identified, specifically around the time of genetic testing and bowel surgery. Associations between FAP and co-occurrent psychiatric disorders and lower cognitive function were suggested.
Conclusions: In conclusion, there is some evidence that co-occurrent psychiatric disorders and intellectual deficits are more prevalent in FAP-patients compared to the general population. During genetic testing and bowel surgery, distress, anxiety and depressive symptoms in subgroups of FAP-patients might be increased. As FAP is a rare disease and sample sizes were small, firm conclusions cannot be drawn. Large prospective studies on mental health issues over time are needed.
期刊介绍：
Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology.
This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues.
Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.
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