Assessment of myocardial dysfunction of patients with systemic lupus erythematosus based on myocardial perfusion imaging and analysis of potential influencing factors.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-06-01 Epub Date: 2025-04-14 DOI:10.1177/09612033251335808
Kejing Shao, Fenghong Yuan, Fei Chen, Wei Hu, Bao Zhu
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Abstract

The incidence and prevalence of systemic lupus erythematosus (SLE) have increased annually over the past decade. The involvement of myocardium is one of the main reasons for the poor prognosis of patients with SLE. Identifying myocardial involvement in patients with autoimmune diseases and providing early targeted treatment can improve patient outcomes. The aim of this study is to evaluate myocardial dysfunction in patients with SLE using 99mTc-MIBI rest gated myocardial perfusion imaging (rGMPI) and to investigate factors associated with myocardial dysfunction. 76 patients with SLE were prospectively enrolled in the study and 46 patients without autoimmune diseases or other inflammatory diseases who had undergone 99mTc-MIBI rGMPI were selected as a control group. Results of relevant blood test indicators, echocardiography and rGMPI were recorded, and comparison was made between the two groups. Meanwhile, based on diagnostic results of rGMPI, SLE patients were divided into myocardial dysfunction group and normal myocardial function group and to analyze the influencing factors of myocardial dysfunction in SLE patients. The incidence of myocardial dysfunction was significantly higher in SLE patients than in controls (30.3% vs 0%, 2= 16.131, p < .001). Moderate/severe disease activity, decreased myocardial perfusion and positive anti-SSA/Ro52kDa antibody were associated with impaired myocardial function in SLE patients (OR = 2.753, 5.359, 3.646; p = .049, 0.015, 0.014). Positive anti-SSA/Ro52kDa antibody was is independently correlated with myocardial dysfunction in SLE patients [OR (95% CI) = 3.159 (1.071-9.316), p = .037]. In conclusion, 99mTc-MIBI rGMPI can noninvasively evaluate myocardial dysfunction in patients with SLE and provide evidence for clinical treatment decisions. Positive anti-SSA/Ro52kDa antibody was an independent risk factor for myocardial dysfunction in SLE patients.

基于心肌灌注显像评价系统性红斑狼疮患者心肌功能障碍及潜在影响因素分析。
在过去的十年中,系统性红斑狼疮(SLE)的发病率和患病率每年都在增加。心肌受累是SLE患者预后不良的主要原因之一。识别自身免疫性疾病患者的心肌受累并提供早期靶向治疗可以改善患者的预后。本研究的目的是利用99mTc-MIBI静息门控心肌灌注成像(rGMPI)评估SLE患者的心肌功能障碍,并探讨心肌功能障碍的相关因素。76例SLE患者被前瞻性纳入研究,46例无自身免疫性疾病或其他炎症性疾病且接受99mTc-MIBI rGMPI治疗的患者作为对照组。记录两组患者相关血检指标、超声心动图及rGMPI结果,并进行比较。同时,根据rGMPI诊断结果,将SLE患者分为心肌功能障碍组和心肌功能正常组,分析SLE患者心肌功能障碍的影响因素。SLE患者心肌功能障碍发生率明显高于对照组(30.3% vs 0%, 2= 16.131, p < 0.001)。中度/重度疾病活动度、心肌灌注减少和抗ssa /Ro52kDa抗体阳性与SLE患者心肌功能受损相关(OR = 2.753, 5.359, 3.646;P = 0.049, 0.015, 0.014)。抗ssa /Ro52kDa抗体阳性与SLE患者心肌功能障碍独立相关[OR (95% CI) = 3.159 (1.071 ~ 9.316), p = 0.037]。综上所述,99mTc-MIBI rGMPI可无创评价SLE患者心肌功能障碍,为临床治疗决策提供依据。抗ssa /Ro52kDa抗体阳性是SLE患者心肌功能障碍的独立危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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