[¹⁸F]NaF PET/CT Imaging of Iliac Bones to Assess Bone Turnover.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Biology Pub Date : 2025-06-01 Epub Date: 2025-04-24 DOI:10.1007/s11307-025-02003-6

Shashi B Singh, Om H Gandhi, Bimash B Shrestha, Patrick Glennan, Anuradha Rosario Bahadur, Niloofaralsadat Motamedi, Kishor Khanal, Sagar Wagle, Poul Flemming Høilund-Carlsen, Thomas J Werner, Mona-Elisabeth Revheim, Abass Alavi

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Abstract

Purpose: This study investigated the effects of laterality, age, gender, BMI, and physical activity level on iliac bone turnover using [¹⁸F]NaF PET/CT.

Procedures: Fifty-nine males and 44 females from the CAMONA study were analyzed. A region of interest (ROI) was drawn to segment the iliac bone using Hounsfield unit thresholds and morphological closing algorithm. [¹⁸F]NaF SUVmean was compared between the left and right iliac bones using a paired t-test, while Pearson correlation coefficient assessed changes with age, BMI, and physical activity level.

Results: [¹⁸F]NaF uptake was higher in right iliac bone than left in males, females, and the combined-group. In males, SUVmean was 2.98 ± 1.63 (1.1-7.87) on left and 3.71 ± 1.49 (1.49-3.7) on right. In females, SUVmean was 2.59 ± 1.14 (0.88-6.27) on left and 3.72 ± 1.04 (2.22-6.51) on right. Combined, SUVmean was 2.81 ± 1.44 (0.88-7.87) on left and 3.71 ± 1.31 (0.89-8.07) on right. [¹⁸F]NaF uptake negatively correlated with age (right: r = - 0.27, P = 0.006; left: r = - 0.22, P = 0.02), stronger in females (right: r = - 0.30, P = 0.04; left: r = - 0.31, P = 0.04) than males (right: r = - 0.26, P = 0.04; left: r = - 0.18, P = 0.18). SUVmean correlated positively with BMI in males (right: r = 0.47, P = 0.0002; left: r = 0.38, P = 0.0027), females (right: r = 0.36, P = 0.0168; left: r = 0.30, P = 0.0505), and combined-group (right: r = 0.43, P < 0.0001; left: r = 0.37, P = 0.0001). No significant correlation was found between SUVmean and physical activity in males, while in females, a negative correlation was observed on left (r = - 0.37, P = 0.0390) but not on right (r = - 0.27, P = 0.1302), and when combined, the correlation remained significant on left (r = - 0.24, P = 0.0372) but not on right (r = - 0.16, P = 0.1541).

Conclusions: [¹⁸F]NaF uptake was higher in the right iliac bone and declined with age, particularly in females. The positive correlation between SUVmean and BMI; and the negative correlation between SUVmean and physical activity suggest metabolic influences on bone turnover. [¹⁸F]NaF PET/CT may serve as a tool for assessing bone metabolism and turnover in asymptomatic individuals.

Abstract Image

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[18F]NaF PET/CT成像评估髂骨骨转换。

目的：本研究利用[18F]NaF PET/CT研究侧位、年龄、性别、BMI和体力活动水平对髂骨转换的影响。程序：对来自CAMONA研究的59名男性和44名女性进行分析。采用Hounsfield单元阈值和形态学闭合算法绘制感兴趣区域（ROI）对髂骨进行分割。[18F]采用配对t检验比较左右髂骨的NaF SUVmean， Pearson相关系数评估随年龄、BMI和体力活动水平的变化。结果：[18F]男性、女性及联合用药组右髂骨NaF摄取均高于左髂骨。男性左、右分别为2.98±1.63（1.1 ~ 7.87）、3.71±1.49（1.49 ~ 3.7）。女性左、右分别为2.59±1.14（0.88-6.27）、3.72±1.04（2.22-6.51）。左、右分别为2.81±1.44（0.88-7.87）、3.71±1.31（0.89-8.07）。[18F]NaF摄取与年龄呈负相关(右：r = - 0.27, P = 0.006；左:r = - 0.22, P = 0.02),在雌性(正确的:r = - 0.30, P = 0.04;左:r = - 0.31, P = 0.04)比男性(正确的:r = - 0.26, P = 0.04;左：r = - 0.18, P = 0.18)。男性SUVmean与BMI呈正相关(右：r = 0.47, P = 0.0002；左侧：r = 0.38, P = 0.0027)，女性(右侧：r = 0.36, P = 0.0168；左：r = 0.30, P = 0.0505)，右：r = 0.43, P < 0.0001；左：r = 0.37, P = 0.0001)。男性的SUVmean与体力活动之间无显著相关，而女性的左侧呈负相关（r = - 0.37, P = 0.0390），右侧呈负相关（r = - 0.27, P = 0.1302），合并后左侧呈显著相关（r = - 0.24, P = 0.0372），右侧无显著相关（r = - 0.16, P = 0.1541）。结论：[18F]右髂骨NaF摄取较高，且随年龄增长而下降，尤其是女性。SUVmean与BMI呈正相关；suv平均值和体力活动之间的负相关表明代谢对骨转换有影响。[18F]NaF PET/CT可作为评估无症状个体骨代谢和转换的工具。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.