Relationship Between TGF-β1 and Left Ventricular Geometry and Function in Patients With Essential Hypertension.

IF 1.4 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-05-10 DOI:10.1002/jcu.24055

Ran Hou, Wen Shui, Xueqing Xing, Yaodong Chen, Wenqian Shen, Qingfei Song, Jian Wang

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引用次数: 0

Abstract

Objective: To explore the association of transforming growth factor β1 (TGF-β1) with left ventricular geometry (LVG) and left ventricular function (LVF) in cases having essential hypertension.

Methods: This retrospective study of 213 cases of essential hypertension, according to echocardiogram measurements, were split into normal geometry (NG), concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH) groups. General clinical data of each patient was analyzed and office blood pressure measurements were performed. Detection of blood biochemistry and serum TGF-β1 content was conducted. The association of TGF-β1 with LVG and LVF parameters was assessed.

Results: In contrast to the NG and CR groups, the TGF-β1 concentration was higher in the EH and CH groups, and it was most pronounced in the CH group. The TGF-β1 was positively linked to E/e' (r = 0.506, p < 0.001), whereas left ventricular global longitudinal strain (GLS) (r = -0.447, p < 0.001) was negatively correlated. Moreover, serum TGF-β1 levels were independently linked to EH and CH.

Conclusion: TGF-β1 was associated with abnormal LVG and LVF in cases of essential hypertension, indicating that it may induce LVG and LVF abnormalities.

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TGF-β1与原发性高血压患者左心室形态及功能的关系

目的：探讨原发性高血压患者转化生长因子β1 （TGF-β1）与左心室几何形状（LVG）和左心室功能（LVF）的关系。方法：对213例原发性高血压患者进行回顾性研究，根据超声心动图测量结果将其分为正常几何组（NG）、同心重构组（CR）、偏心肥厚组（EH）和同心肥厚组（CH）。分析每位患者的一般临床资料，并进行办公室血压测量。检测血液生化及血清TGF-β1含量。评估TGF-β1与LVG及LVF参数的相关性。结果：与NG和CR组相比，EH和CH组TGF-β1浓度较高，且以CH组最为明显。TGF-β1与E/ E′呈正相关（r = 0.506, p）结论：TGF-β1与原发性高血压患者LVG和LVF异常相关，提示其可能诱导LVG和LVF异常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.