Efficacy of Thrombin Solution Injection Combined with Rapid Biopsy-Side Down Position Technique in CT-guided Lung Biopsy: A Propensity Score Matching Analysis.

Abstract

Objective: The objective of this study is to investigate the effect of thrombin solution injection combined with the rapid biopsy-side down position technique on the incidence of pneumothorax in emphysema patients following computed tomography (CT)-guided lung biopsy based on propensity score matching.

Materials & methods: A retrospective study was conducted on emphysema patients who underwent CT-guided percutaneous lung biopsy between May 2022 and July 2023. Patients were divided into two groups based on the use of the rapid biopsy-side-down position technique. Propensity score matching was then applied to explore correlations.

Results: A total of 212 patients were included in the study. Before propensity score matching, there were no significant differences between Groups A and B in terms of sex, lesion size, puncture path length, or patient positioning in multivariate logistic regression analysis. After matching with a 1:1 ratio, 41 patients were successfully paired. Logistic regression analysis revealed that the rapid biopsy-side down position technique was significantly correlated with a reduced incidence of pneumothorax (p = 0.027), serving as a protective factor.

Conclusion: The combination of thrombin solution injection and the rapid biopsy-side down position technique significantly reduces the incidence of pneumothorax in emphysema patients following CT-guided lung biopsy.