Association between GLIM diagnosed malnutrition and 18-month mortality in hospitalized adults with congestive heart failure: A prospective cohort study

IF 4.1 3区医学 Q2 NUTRITION & DIETETICS

Journal of Parenteral and Enteral Nutrition Pub Date : 2025-04-13 DOI:10.1002/jpen.2760

Ruoshu Duan MD, PhD, Suxiu Chen MM, Suxia Li MM, Jie Ding MD, Lei Wang MD, PhD, Yangli Li MM, Jingjing Ren MD, Sujing Jiang MD

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Abstract

Background

The Global Leadership Initiative on Malnutrition (GLIM) criteria have been validated in various clinical settings since 2018, but prospective validation in patients with congestive heart failure (CHF) who are hospitalized remains limited. This study compares the prognostic performance of the GLIM criteria and Mini-Nutritional Assessment (MNA)-defined malnutrition for all-cause mortality in CHF patients and explores the strongest predictive indicator within the GLIM criteria.

Methods

This single-center prospective cohort study included inpatients with CHF. Agreement between the GLIM criteria and MNA was assessed using Cohen κ coefficient. Survival data were analyzed using Kaplan-Meier curves and adjusted Cox regression analyses.

Results

Among 498 CHF inpatients, 84 (16.9%) died during the 18-month follow-up. Malnutrition prevalence was 47.2% and 50.4% based on the GLIM criteria and MNA, respectively (κ = 0.68; P < 0.001). Malnutrition was independently associated with a higher risk of all-cause mortality (GLIM criteria: hazard ratio, 2.16 [95% confidence interval (CI), 1.13–4.13]; MNA: hazard ratio, 4.28 [95% CI, 1.98–9.22]). Low body mass index was the strongest predictor of all-cause mortality in multivariable analysis (hazard ratio, 5.14; 95% CI, 3.19–8.27).

Conclusion

The GLIM criteria showed strong consistency with MNA and effectively predicted all-cause mortality in CHF patients within 18 months.

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GLIM诊断的营养不良与充血性心力衰竭住院成人18个月死亡率之间的关系：一项前瞻性队列研究。

背景：自2018年以来，营养不良全球领导倡议（GLIM）标准已在各种临床环境中得到验证，但对住院的充血性心力衰竭（CHF）患者的前瞻性验证仍然有限。本研究比较了GLIM标准和微型营养评估（MNA）定义的营养不良对心力衰竭患者全因死亡率的预后表现，并探讨了GLIM标准中最强的预测指标。方法：该单中心前瞻性队列研究纳入住院CHF患者。使用Cohen κ系数评估GLIM标准与MNA之间的一致性。生存数据采用Kaplan-Meier曲线和校正Cox回归分析。结果：498例CHF住院患者中，84例（16.9%）在18个月随访期间死亡。根据GLIM标准和MNA，营养不良患病率分别为47.2%和50.4% (κ = 0.68；结论：GLIM标准与MNA具有较强的一致性，可有效预测CHF患者18个月内的全因死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Parenteral and Enteral Nutrition 医学-营养学

CiteScore

7.80

自引率

8.80%

发文量

161

审稿时长

6-12 weeks

期刊介绍： The Journal of Parenteral and Enteral Nutrition (JPEN) is the premier scientific journal of nutrition and metabolic support. It publishes original peer-reviewed studies that define the cutting edge of basic and clinical research in the field. It explores the science of optimizing the care of patients receiving enteral or IV therapies. Also included: reviews, techniques, brief reports, case reports, and abstracts.