Flow Reserve Does Not Predict Long-Term Outcomes After Transaortic Valve Implantation in Patients With Preserved Left Ventricular Ejection Fraction.

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-04-28 DOI:10.1002/jcu.24034

Marte Sævik, Jan O Beitnes, Lars Aaberge, Per S Halvorsen

{"title":"Flow Reserve Does Not Predict Long-Term Outcomes After Transaortic Valve Implantation in Patients With Preserved Left Ventricular Ejection Fraction.","authors":"Marte Sævik, Jan O Beitnes, Lars Aaberge, Per S Halvorsen","doi":"10.1002/jcu.24034","DOIUrl":null,"url":null,"abstract":"Purpose: We aimed to assess if flow reserve (FR) in low-dose dobutamine stress echocardiography (DSE) could predict major cardiovascular events (MACE) 1 year after TAVI in patients with severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF). We also explored the relationship between FR and NYHA class, 6-min walk test, left ventricular function, and quality of life (SF-36).Methods: The DSE protocol (n = 72) was performed up to 20 μg/kg/min preoperatively, and FR was defined as ≥ 20% increase in stroke volume (SV). Echocardiography, walking test, and SF-36 were repeated at 12 months follow-up.Results: Average age was 80 ± 5 years. Preoperative peak aortic valve velocity was 4.7 ± 0.6 m/s and LVEF was 65% ± 9%. SV increased from 81 ± 19 to 92 ± 20 mL during the DSE. Twenty-five patients (36%) had FR. The prevalence of MACE was 13% at follow-up. Patients with or without FR had no significant differences in MACE (p = 1.000), NYHA class (p = 0.375), walking distance (p = 0.262), left ventricular function, or quality of life.Conclusion: FR in DSE could not predict long-term outcomes after TAVI, and offered no additional prognostic value for this patient group.","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Ultrasound","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jcu.24034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ACOUSTICS","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: We aimed to assess if flow reserve (FR) in low-dose dobutamine stress echocardiography (DSE) could predict major cardiovascular events (MACE) 1 year after TAVI in patients with severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF). We also explored the relationship between FR and NYHA class, 6-min walk test, left ventricular function, and quality of life (SF-36).

Methods: The DSE protocol (n = 72) was performed up to 20 μg/kg/min preoperatively, and FR was defined as ≥ 20% increase in stroke volume (SV). Echocardiography, walking test, and SF-36 were repeated at 12 months follow-up.

Results: Average age was 80 ± 5 years. Preoperative peak aortic valve velocity was 4.7 ± 0.6 m/s and LVEF was 65% ± 9%. SV increased from 81 ± 19 to 92 ± 20 mL during the DSE. Twenty-five patients (36%) had FR. The prevalence of MACE was 13% at follow-up. Patients with or without FR had no significant differences in MACE (p = 1.000), NYHA class (p = 0.375), walking distance (p = 0.262), left ventricular function, or quality of life.

Conclusion: FR in DSE could not predict long-term outcomes after TAVI, and offered no additional prognostic value for this patient group.

查看原文本刊更多论文

血流储备不能预测左心室射血分数保留患者经主动脉瓣植入术后的长期预后。

目的：我们旨在评估低剂量多巴酚丁胺应激超声心动图（DSE）的血流储备（FR）是否可以预测严重主动脉瓣狭窄（AS）和左心室射血分数（LVEF）保留患者TAVI后1年的主要心血管事件（MACE）。我们还探讨了FR与NYHA分级、6分钟步行试验、左心室功能和生活质量（SF-36）之间的关系。方法：术前给药剂量为20 μg/kg/min的DSE方案（n = 72），以卒中容积（SV）增加≥20%为FR。超声心动图、行走试验、SF-36随访12个月。结果：平均年龄80±5岁。术前主动脉瓣速度峰值为4.7±0.6 m/s， LVEF为65%±9%。在DSE期间，SV从81±19 mL增加到92±20 mL。25例患者（36%）有FR。随访时MACE患病率为13%。伴有或不伴有FR的患者在MACE （p = 1.000）、NYHA分级（p = 0.375）、步行距离（p = 0.262）、左心室功能或生活质量方面无显著差异。结论：DSE的FR不能预测TAVI后的长期预后，对该患者组没有额外的预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.