Postpartum Depression Increases the Risk of Childhood Attention Deficit Hyperactivity Disorder Diagnosis.

IF 2.6 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Darios Getahun, Michael J Fassett, Nana A Mensah, Nehaa Khadka, Meiyu Yeh, Vicki Y Chiu, Yinka Oyelese, Morgan R Peltier
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Abstract

Postpartum Depression (PPD) is a common adverse pregnancy outcome, but the extent to which PPD correlates with attention deficit hyperactivity disorder (ADHD) in the offspring is unclear. Therefore, we examined if children of mothers who experienced PPD are at risk for developing ADHD and how this association may be modified by the child's sex, race/ethnicity, and gestational age at delivery. A retrospective cohort study of singleton-born children aged 3-12 years and delivered in Kaiser Permanente Southern California hospitals between 01/01/2010-12/31/2019 (n = 229,860) was performed using electronic health records. ICD- 9-CM and ICD- 10-CM codes and pharmacy records were used to ascertain exposure and outcomes of interest. Incidence rates and adjusted hazard ratios (aHR) were estimated to quantify the association between PPD and childhood ADHD. Children of women with PPD were more likely to be diagnosed with ADHD than children of women without PPD (8.85 vs. 5.18/1000 person-years, aHR = 1.76, confidence interval (CI): 1.66-1.86). Among women who delivered at 29-32 and 33-36 weeks of gestation, PPD was associated with 1.61-fold (95% CI: 1.06-2.57) and 1.72-fold (95% CI: 1.44-2.06) increased risk of ADHD, respectively, compared to pregnancies without a history of PPD. PPD was associated with an increased ADHD risk for all racial/ethnic groups and both child sex categories. PPD may help identify at-risk children who could benefit from earlier surveillance and interventions. Additional studies are needed to determine if PPD has a causal relationship with ADHD or if these conditions have a common risk factor.

产后抑郁症增加儿童注意缺陷多动障碍诊断的风险。
产后抑郁(PPD)是一种常见的不良妊娠结局,但PPD与后代注意缺陷多动障碍(ADHD)的关联程度尚不清楚。因此,我们研究了患有产后抑郁症的母亲的孩子是否有患多动症的风险,以及这种关联如何被孩子的性别、种族/民族和分娩时的胎龄所改变。采用电子健康记录对2010年1月1日至2019年12月31日期间在Kaiser Permanente南加州医院分娩的3-12岁单胎儿童(n = 229,860)进行回顾性队列研究。使用ICD- 9-CM和ICD- 10-CM代码和药房记录来确定暴露和感兴趣的结果。估计发病率和校正风险比(aHR)来量化PPD和儿童ADHD之间的关系。患有PPD的妇女的孩子比没有PPD的妇女的孩子更容易被诊断为ADHD (8.85 vs. 5.18/1000人年,aHR = 1.76,置信区间(CI): 1.66-1.86)。在妊娠29-32周和33-36周分娩的妇女中,与没有PPD病史的孕妇相比,PPD的ADHD风险分别增加1.61倍(95% CI: 1.06-2.57)和1.72倍(95% CI: 1.44-2.06)。在所有种族/民族和两种儿童性别类别中,PPD与多动症风险增加有关。产后抑郁症可能有助于识别那些可能从早期监测和干预中受益的高危儿童。需要进一步的研究来确定PPD是否与ADHD有因果关系,或者这些情况是否有共同的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reproductive Sciences
Reproductive Sciences 医学-妇产科学
CiteScore
5.50
自引率
3.40%
发文量
322
审稿时长
4-8 weeks
期刊介绍: Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
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