Test-retest reliability of Cirrus HD-optical coherence tomography retinal layer thickness measurements in people with multiple sclerosis.

IF 2.5 Q2 CLINICAL NEUROLOGY

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2025-05-11 eCollection Date: 2025-04-01 DOI:10.1177/20552173251340957

Anna Bacchetti, Brenna McCormack, Ting-Yi Lin, Rozita Doosti, Gelareh Ahmadi, Omar Ezzedin, Nicole Pellegrini, Evan Johnson, Anna Kim, Gabriel Otero-Duran, Devon J Bonair, Elle Lawrence, Ernest Lievers, Simidele Davis, Sooyeon Park, Madeline Inserra, Ananya Gulati, Kathryn C Fitzgerald, Elias S Sotirchos, Peter A Calabresi, Shiv Saidha

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Abstract

Background: Optical coherence tomography (OCT) allows evaluation of inter-eye differences (IEDs) in peri-papillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses to identify unilateral optic nerve involvement (UONI), which is included in the 2024 revised McDonald diagnostic criteria for multiple sclerosis (MS).

Objectives: To evaluate the test-retest reliability of pRNFL and GCIPL thicknesses/IEDs in people with MS, other neurological disorders, and healthy controls using Cirrus HD-OCT.

Methods: 509 participants underwent Cirrus HD-OCT, acquiring two macular and optic disc scans per eye within each session. Scans meeting OSCAR-IB quality control criteria were included in final analyses (959 eyes), with no clinical/demographic exclusions (reflecting a real-world clinical setting). Reliability was assessed using coefficients of variation (COVs), intraclass correlation coefficients (ICCs), and Bland-Altman limits of agreement (LOA). IED consistency was evaluated using difference-in-differences (DiDs) of test-retest measurements.

Results: GCIPL demonstrated superior reliability (ICC: 0.998, COV: 0.40%, LOA: -1.29 to 1.35 μm) to pRNFL (ICC: 0.989, COV: 1.18%, LOA: -3.59 to 3.70 μm) thickness. Inter-eye absolute DiDs [pRNFL: 2.00 μm (standard deviation (SD) 1.73); GCIPL: 0.64 μm (SD 0.67)] were lower than IED thresholds proposed for identifying UONI.

Conclusions: The excellent reliability of GCIPL and pRNFL thicknesses/IEDs support OCT for identifying UONI to diagnose MS.

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Cirrus hd光学相干断层扫描视网膜层厚度测量在多发性硬化症患者中的测试-重测可靠性。

背景：光学相干断层扫描（OCT）可以评估乳头周围视网膜神经纤维层（pRNFL）和黄斑神经节细胞-内丛状层（GCIPL）厚度的眼间差异（IEDs），以识别单侧视神经受累（UONI），这被纳入2024年修订的多发性硬化症（MS）麦克唐纳诊断标准。目的：利用Cirrus HD-OCT评估MS、其他神经系统疾病患者和健康对照者pRNFL和GCIPL厚度/ ids的重测信度。方法：509名参与者接受了Cirrus HD-OCT，在每次治疗中每只眼睛进行两次黄斑和视盘扫描。符合OSCAR-IB质量控制标准的扫描纳入最终分析（959只眼睛），没有临床/人口统计学排除（反映现实世界的临床环境）。采用变异系数（COVs）、类内相关系数（ICCs）和Bland-Altman一致限（LOA）评估可靠性。使用重测测量的差中差（DiDs）评估IED一致性。结果：GCIPL对pRNFL厚度（ICC: 0.989, COV: 1.18%, LOA: -3.59 ~ 3.70 μm）具有较好的信度（ICC: 0.998, COV: 0.40%, LOA: -1.29 ~ 1.35 μm）。眼间绝对DiDs [pRNFL: 2.00 μm（标准差（SD） 1.73）；GCIPL: 0.64 μm (SD 0.67)]低于IED提出的鉴别UONI的阈值。结论：GCIPL和pRNFL厚度/IEDs具有良好的可靠性，支持OCT鉴别UONI诊断MS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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