Proportions of US Blood Donors With Serological Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections Who Reported Survey-Based Diagnosed Infections During July 2020-December 2022.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-04-10 eCollection Date: 2025-05-01 DOI:10.1093/ofid/ofaf210

Akintunde Akinseye, David J Wright, Eduard Grebe, Mars Stone, Cassandra A Hathaway, Rebecca V Fink, Bryan R Spencer, Paula Saa, Marion C Lanteri, Michael Busch, Jefferson M Jones

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Abstract

The proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections diagnosed by coronavirus disease 2019 (COVID-19) tests, including home antigen tests, is unknown. We detected infections among blood donors in the United States (US) by testing for nucleocapsid antibody (anti-N) seroconversion and administered a questionnaire to determine the proportion of those infections that were associated with a self-reported positive COVID-19 test. Among US blood donors with serologic evidence of SARS-CoV-2 infection who completed a survey, 47.7% reported an associated self-reported positive COVID-19 test. This proportion changed from July-December 2020 (44.9%) to July-December 2022 (54.8%). This study suggests many SARS-CoV-2 infections in adults are not diagnosed with a test.

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在2020年7月至2022年12月期间，有严重急性呼吸综合征冠状病毒2感染血清学证据的美国献血者报告基于调查的诊断感染的比例

通过2019冠状病毒病（COVID-19）检测（包括家庭抗原检测）诊断出的严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）感染的比例尚不清楚。我们通过检测核衣壳抗体（anti-N）血清转化来检测美国献血者中的感染，并进行问卷调查，以确定与自我报告的COVID-19检测阳性相关的感染比例。在完成调查的有SARS-CoV-2感染血清学证据的美国献血者中，47.7%的人报告了相关的自我报告的COVID-19检测阳性。这一比例从2020年7月至12月（44.9%）到2022年7月至12月（54.8%）发生了变化。这项研究表明，许多成年人的SARS-CoV-2感染没有通过检测来诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.