Association between weather conditions and migraine: a systematic review and meta-analysis.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-04-17 DOI:10.1007/s00415-025-13078-0

Shiqin Li, Qian Liu, Mengmeng Ma, Jinghuan Fang, Li He

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引用次数: 0

Abstract

Background: Previous studies have linked migraine to weather conditions, but variations in the factors examined and inconsistent focus have complicated comparisons. This underscores the need for a more comprehensive and clearer analysis.

Methods: Studies published before December 2024 on the association between weather and migraine were searched from PubMed, Embase, Web of Science, and Cochrane. Meta-analyses based on effect sizes were performed using Review Manager version 5.4.1.

Results: A total of 31 studies were included in the meta-analyses. It revealed a significant association between migraine attack and weather changes reported as a trigger factor (RD = 0.47, 95% CI = 0.40-0.54). Additionally, specific weather factors, such as temperature (OR = 1.15, 95% CI = 1.02-1.29) and ambient pressure (OR = 1.07, 95% CI = 1.01-1.15), were significantly associated with migraine attacks, while humidity (OR = 1.04, 95% CI = 0.97-1.11) did not show a significant association. Moreover, increased levels of air pollutants, including PM10 (OR = 1.07, 95% CI = 1.03-1.11), PM2.5 (OR = 1.04, 95% CI = 1.01-1.06), NO₂ (OR = 1.08, 95% CI = 1.03-1.14), CO (OR = 1.08, 95% CI = 1.01-1.16), and O₃ (OR = 1.12, 95% CI = 1.03-1.21), were significantly associated with an increased risk of migraine clinical visits, whereas SO₂ (OR = 1.02, 95% CI = 1.00-1.04) was not.

Conclusions: This meta-analysis revealed that weather changes are significant trigger factors for migraine, with temperature and ambient pressure playing notable roles in this association. Additionally, increased levels of air pollutants are linked to a higher risk of migraine attacks. These findings could lead to new interventions for patients who are weather-sensitive and offer fresh perspectives for future research into the pathogenesis of migraine.

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天气状况与偏头痛之间的关系：一项系统回顾和荟萃分析。

背景：以前的研究将偏头痛与天气条件联系起来，但检查因素的变化和不一致的焦点使比较变得复杂。这突出表明需要进行更全面和更明确的分析。方法：从PubMed、Embase、Web of Science和Cochrane检索2024年12月之前发表的关于天气与偏头痛之间关系的研究。基于效应量的meta分析使用Review Manager版本5.4.1进行。结果：meta分析共纳入31项研究。它揭示了偏头痛发作与天气变化之间的显著关联，天气变化被报道为触发因素（RD = 0.47, 95% CI = 0.40-0.54）。此外，特定的天气因素，如温度（OR = 1.15, 95% CI = 1.02-1.29）和环境压力（OR = 1.07, 95% CI = 1.01-1.15）与偏头痛发作显著相关，而湿度（OR = 1.04, 95% CI = 0.97-1.11）没有显示出显著的关联。此外，空气污染物水平的增加，包括PM10 （OR = 1.07, 95% CI = 1.03-1.11）、PM2.5 （OR = 1.04, 95% CI = 1.01-1.06）、NO2 （OR = 1.08, 95% CI = 1.03-1.14）、CO （OR = 1.08, 95% CI = 1.01-1.16）和O3 (OR = 1.12, 95% CI = 1.03-1.21)，与偏头痛临床就诊风险的增加显著相关，而SO2 （OR = 1.02, 95% CI = 1.00-1.04）则无关。结论：这项荟萃分析显示，天气变化是偏头痛的重要触发因素，温度和环境压力在这一关联中起着显著作用。此外，空气污染物水平的增加与偏头痛发作的风险增加有关。这些发现可能为天气敏感的患者提供新的干预措施，并为未来偏头痛发病机制的研究提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.