GLP-1 Agonist Use Among Men With Localized Prostate Cancer: A Narrative Review and Rationale for Prospective Clinical Trials.

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology Pub Date : 2025-05-29 DOI:10.1016/j.urology.2025.04.056

Andrew Fang, Daniel E Frigo, Andrew Hahn, Zayd Razouki, Jessica Hwang, Efstratios Koutroumpakis, Tarek Lawen, Matthew Smith, Jill Hamilton-Reeves, John DiGiovanni, Noel Higgason, Rebekka S Garcia, Brian F Chapin, Curtis Pettaway, Lisly Chery, Patricia Troncoso, Christopher Logothetis, Carrie R Daniel, Peng Wei, Justin R Gregg

引用次数: 0

Abstract

Glucagon-like peptide 1 (GLP-1) receptor agonists are a revolutionary treatment for obesity, and investigations into other uses of these agents are ongoing. Epidemiologic data suggest that prostate cancer risk may decrease following GLP-1 receptor agonist initiation. To better define the potential role of GLP-1 receptor agonist use among men with prostate cancer, we will define changes that occur in men with prostate cancer following lifestyle intervention; illuminate the current relationship between these interventions and prostate cancer risk; and explore the potential mechanism of action on tumor biology, providing rationale for evaluating its effects on prostate cancer in a planned clinical trial.

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GLP-1激动剂在局限性前列腺癌患者中的应用：前瞻性临床试验的叙述回顾和基本原理。

GLP-1受体激动剂是一种革命性的肥胖治疗方法，对这些药物的其他用途的研究正在进行中。流行病学数据表明，GLP-1受体激动剂启动后，前列腺癌风险可能降低。为了更好地确定GLP-1受体激动剂在前列腺癌患者中的潜在作用，我们将确定生活方式干预后前列腺癌患者的变化；阐明目前这些干预措施与前列腺癌风险之间的关系；并探讨其对肿瘤生物学的潜在作用机制，为在计划中的临床试验中评估其对前列腺癌的作用提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

9.50%

发文量

716

审稿时长

59 days

期刊介绍： Urology is a monthly, peer–reviewed journal primarily for urologists, residents, interns, nephrologists, and other specialists interested in urology The mission of Urology®, the "Gold Journal," is to provide practical, timely, and relevant clinical and basic science information to physicians and researchers practicing the art of urology worldwide. Urology® publishes original articles relating to adult and pediatric clinical urology as well as to clinical and basic science research. Topics in Urology® include pediatrics, surgical oncology, radiology, pathology, erectile dysfunction, infertility, incontinence, transplantation, endourology, andrology, female urology, reconstructive surgery, and medical oncology, as well as relevant basic science issues. Special features include rapid communication of important timely issues, surgeon''s workshops, interesting case reports, surgical techniques, clinical and basic science review articles, guest editorials, letters to the editor, book reviews, and historical articles in urology.