Comparison of visual function and patient-reported outcomes between two full range of field intraocular lenses: a randomized controlled study.

Abstract

Purpose: To compare visual and patient-reported outcomes in patients with cataracts bilaterally implanted with PanOptix or Synergy intraocular lenses (IOLs).

Settings: 5 sites in the United States.

Design: Prospective, parallel-arm randomized patient- and examiner-masked clinical study.

Methods: Adult cataract patients (≥22 years) were randomized (1:1) to receive bilateral PanOptix or Synergy IOL implantation. Study endpoints: Binocular uncorrected and distance-corrected VA (logMAR) at distance, intermediate (60 cm), near (40 and 33 cm); defocus curve; patient-reported visual disturbances, spectacle independence, and visual satisfaction using questionnaires at 6 months; binocular contrast sensitivity at 3 months.

Results: At 6 months, PanOptix (n = 138) was non-inferior to Synergy (n = 138) IOLs for photopic binocular uncorrected and distance-corrected VA at all tested distances (P < .05). Mesopic intermediate and near VA showed a similar trend. Defocus curves showed that both IOLs provided VA of ≤0.1 logMAR from -2.50 D to +0.50 D and <0.2 logMAR at -3.00 D. A significantly lower proportion of patients with PanOptix (vs Synergy) experienced starbursts and glare (P < .05). Most patients in both groups reported never/rarely needing eyeglasses to see and high satisfaction with vision. Both IOLs provided similar binocular contrast sensitivity at 3 months under photopic and mesopic conditions.

Conclusions: PanOptix IOLs provided a similar full range of vision, spectacle independence, and contrast sensitivity, but superior tolerance to glare and starbursts, compared to Synergy IOLs.