The role of β-adrenergic receptors in mediating exercise hyperemia during incremental single-leg knee extension in young males and females.

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Journal of applied physiology Pub Date : 2025-06-01 Epub Date: 2025-05-05 DOI:10.1152/japplphysiol.00896.2024
Connor J Doherty, Benjamin P Thompson, Paige J Rynne, Jou-Chung Chang, Alexis E Pulford-Thorpe, Sarah A Angus, Eva C M Fleming, Sean L Gartner, Jason S Au, Glen E Foster, Paolo B Dominelli
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Abstract

Previous research has identified a role for β-adrenergic receptors in mediating sex differences in blood pressure regulation at rest. β-receptors are also involved in the exercise hyperemia response during low-intensity small muscle mass exercise in males. However, less is known about β-adrenergic receptors in mediating local exercise hyperemia response during graded large muscle mass exercise in young males and females. We compared steady-state cardiorespiratory responses, leg blood flow (Q̇LEG), and leg vascular conductance (LVC) in 16 participants (8 females) at rest and during incremental knee extension exercise with and without complete nonselective β-adrenergic blockade using propranolol. Propranolol reduced absolute heart rate (HR), Q̇LEG, and LVC responses during exercise. Females had greater absolute increases in HR and lower absolute Q̇LEG and LVC during exercise. However, Q̇LEG and LVC responses to incremental exercise were not different by sex or propranolol, even after normalizing for differences in estimated quadriceps muscle mass. Females were also found to have greater dilation of the femoral artery, which was blunted to a greater extent with propranolol compared with males at absolute exercise intensities. In conclusion, β-adrenergic receptors did not play an important role in mediating the overall exercise hyperemia response in males or females, as the cardiovascular system prioritizes the preservation of oxygen delivery to the exercising muscle. However, β2-adrenergic receptors appear to play a distinct role in mediating sex differences in changes to vascular tone during exercise.NEW & NOTEWORTHY We examined the role of beta-adrenergic receptors (β-ARs) in mediating exercise hyperemia in males and females. No sex differences in leg blood flow or leg vascular conductance, but females exhibited greater dilation of the femoral artery (FA), and β-AR blockade blunted FA dilation in females at absolute exercise intensities. Findings highlight that exercise hyperemia is not reliant on β-ARs and suggest females rely more on β-ARs in mediating vascular tone during exercise.

β-肾上腺素能受体在年轻男性和女性增加单腿膝关节伸展过程中介导运动充血的作用。
先前的研究已经确定了β-肾上腺素能受体在调节休息时血压调节的性别差异中的作用。β受体也参与了男性低强度小肌肉量运动时的运动充血反应。然而,在年轻男性和女性中,β-肾上腺素能受体在分级大肌肉量运动中介导局部运动充血反应的作用尚不清楚。我们比较了16名参与者(8名女性)在休息和增加膝关节伸展运动时的稳态心肺反应、腿部血流量(Q / leg)和腿部血管导度(LVC),并使用了非选择性β-肾上腺素能阻断剂,并没有使用。心得安降低运动时的绝对心率(HR)、Q / LEG和LVC反应。女性在运动过程中HR的绝对增加更大,而Q、LEG和LVC的绝对增加更低。然而,即使在将估计的股四头肌肌肉量的差异归一化后,增量运动的Q / LEG和LVC反应也没有性别或心得安的差异。研究还发现,女性的股动脉扩张更大,在绝对运动强度下,与男性相比,服用心得安会使股动脉钝化得更大。总之,β-肾上腺素能受体在调节男性或女性的整体运动充血反应中没有发挥重要作用,因为心血管系统优先考虑保存向运动肌肉的氧气输送。然而,β2-肾上腺素能受体似乎在调节运动期间血管张力变化的性别差异中发挥着独特的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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