Quantitative T₂ mapping of lung parenchyma at 9.4 T: A feasibility study in three murine models of interstitial lung disease.

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medicine Pub Date : 2025-05-09 DOI:10.1002/mrm.30534

Grzegorz Kwiatkowski, Aleksandra Kaszlikowska, Laura Seldeslachts, Lauren Michiels, Tadeusz Pałasz, Uwe Himmelreich, Greetje Vande Velde, Stefan Chłopicki

{"title":"Quantitative T2 mapping of lung parenchyma at 9.4 T: A feasibility study in three murine models of interstitial lung disease.","authors":"Grzegorz Kwiatkowski, Aleksandra Kaszlikowska, Laura Seldeslachts, Lauren Michiels, Tadeusz Pałasz, Uwe Himmelreich, Greetje Vande Velde, Stefan Chłopicki","doi":"10.1002/mrm.30534","DOIUrl":null,"url":null,"abstract":"Purpose: To validate the feasibility of quantitative T2 mapping as a novel, gadolinium-free, preclinical biomarker of interstitial lung disease (ILD).Methods: Quantitative T2 mapping of lung parenchyma was obtained with multiple-slice multiple-echo readout. A mono-exponential model of magnetization decay was fit to the data to obtain parametric maps of T2 relaxation time in four slices across whole lungs. The measurements were performed in three clinically relevant murine models ILD: acute lung injury due to endotoxemia, chronic recovery phase post-influenza infection, and bleomycin-induced interstitial lung fibrosis.Results: Quantitative maps of T2 relaxation in healthy mice showed a mean value of 10.51 ± 0.56 ms. During ILD development, the mean T2 increased up to threefold, showing high sensitivity to altered tissue water content due to augmented fraction of macromolecules in fibrosis or inflammation associated with disease progression.Conclusion: T2 mapping of mouse lungs can be successfully applied at 9.4 T, offering quantitative insights through parametric T2 mapping across various ILD models without requiring contrast agents. The proposed method for evaluating lung tissue damage is adaptable to other interstitial lung diseases.","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic Resonance in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mrm.30534","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To validate the feasibility of quantitative T₂ mapping as a novel, gadolinium-free, preclinical biomarker of interstitial lung disease (ILD).

Methods: Quantitative T₂ mapping of lung parenchyma was obtained with multiple-slice multiple-echo readout. A mono-exponential model of magnetization decay was fit to the data to obtain parametric maps of T₂ relaxation time in four slices across whole lungs. The measurements were performed in three clinically relevant murine models ILD: acute lung injury due to endotoxemia, chronic recovery phase post-influenza infection, and bleomycin-induced interstitial lung fibrosis.

Results: Quantitative maps of T₂ relaxation in healthy mice showed a mean value of 10.51 ± 0.56 ms. During ILD development, the mean T₂ increased up to threefold, showing high sensitivity to altered tissue water content due to augmented fraction of macromolecules in fibrosis or inflammation associated with disease progression.

Conclusion: T₂ mapping of mouse lungs can be successfully applied at 9.4 T, offering quantitative insights through parametric T₂ mapping across various ILD models without requiring contrast agents. The proposed method for evaluating lung tissue damage is adaptable to other interstitial lung diseases.

查看原文本刊更多论文

9.4 T时肺实质定量T2制图：三种肺间质性疾病小鼠模型的可行性研究

目的：验证定量T2定位作为一种新的、无钆的间质性肺疾病（ILD）临床前生物标志物的可行性。方法：采用多层多回波读出法对肺实质进行定量T2定位。将磁化衰减的单指数模型与数据拟合，得到全肺4片T2弛豫时间的参数图。在三种临床相关的小鼠模型ILD中进行了测量：内毒素血症引起的急性肺损伤，流感感染后的慢性恢复期和博莱霉素诱导的间质性肺纤维化。结果：健康小鼠T2弛豫定量图谱平均值为10.51±0.56 ms。在ILD的发展过程中，平均T2增加到三倍，显示出对组织含水量改变的高度敏感性，这是由于与疾病进展相关的纤维化或炎症中大分子的增加。结论：小鼠肺的T2制图可以在9.4 T成功应用，通过参数化T2制图在各种ILD模型中提供定量见解，而不需要造影剂。所提出的肺组织损伤评价方法也适用于其他间质性肺疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.