Periorbital skin hypopigmentation associated with the use of topical glaucoma medications.

Q3 Medicine
Digital journal of ophthalmology : DJO Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI:10.5693/djo.02.2024.05.001
Sam Karimaghaei, Jeff Yee, Abdelrahman M Elhusseiny
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引用次数: 0

Abstract

Topical medications such as prostaglandin analogues, beta-blockers, alpha-2 agonists, and carbonic anhydrase inhibitors are routinely used for the management of ocular hypertension and glaucoma. Many are associated with adverse effects. We present the case of a 72-year-old woman who developed bilateral periocular hypopigmentation in the setting of long-term use of latanoprost, timolol, and brinzolamide/brimonidine. A well-known side effect of prostaglandin analogues is skin hyperpigmentation, but a few cases of a paradoxical hypopigmentation have been reported. Timolol and brinzolamide/brimonidine have not been associated with changes in skin pigmentation in the ophthalmic literature. Our case most likely represents a rare instance of paradoxical skin depigmentation associated with latanoprost use and adds to the limited literature on this clinical entity.

眼窝周围皮肤色素沉着与局部青光眼药物的使用有关。
局部药物如前列腺素类似物、受体阻滞剂、α -2激动剂和碳酸酐酶抑制剂通常用于高眼压和青光眼的治疗。许多与不良反应有关。我们报告一位72岁的女性,长期使用拉坦前列素、替莫洛尔和布林唑胺/溴莫尼定后,出现双侧眼周色素沉着。前列腺素类似物的一个众所周知的副作用是皮肤色素沉着,但也有一些矛盾的色素沉着的病例被报道。在眼科文献中,噻莫洛尔和溴唑胺/溴胺与皮肤色素沉着的变化没有关联。我们的病例很可能代表了一个罕见的与拉坦前列素使用相关的反常皮肤色素沉着的实例,并增加了关于该临床实体的有限文献。
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来源期刊
Digital journal of ophthalmology : DJO
Digital journal of ophthalmology : DJO Medicine-Medicine (all)
CiteScore
0.80
自引率
0.00%
发文量
14
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