Amniotic fluid: its role in fetal development and beyond.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-05-08 DOI:10.1038/s41372-025-02313-1

B Adam Crosland, Madeline A Hedges, Kimberly S Ryan, Rahul J D'mello, Owen J T Mccarty, Sanjay V Malhotra, Eliot R Spindel, Lyndsey E Shorey-Kendrick, Brian P Scottoline, Jamie O Lo

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引用次数: 0

Abstract

Amniotic fluid is a complex biological medium that surrounds the fetus and offers not only mechanical protection but also provides nutrition and plays a critical role in normal fetal growth, organogenesis, and potentially fetal programming. Despite its importance, the biology of amniotic fluid has been understudied because of ethical and technical challenges in obtaining amniotic fluid samples from healthy human pregnancies, translational limitations of animal models to humans due to species-specific differences. Recent progress in understanding its dynamic physiology, composition, and clinical applications has advanced prenatal care and facilitated improved diagnostic and therapeutic strategies. As research continues to elucidate the complexities and evolutionary function of amniotic fluid, its increasingly recognized role in maternal-fetal medicine and its potential to transform clinical practice will only become more evident. The purpose of this review is to underscore the key roles of amniotic fluid in shaping fetal development and therapeutic potential.

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羊水：在胎儿发育及以后的作用。

羊水是包围胎儿的一种复杂的生物介质，不仅提供机械保护，而且提供营养，在胎儿正常生长、器官发生和潜在的胎儿规划中起着关键作用。尽管羊水很重要，但由于从健康的人类妊娠中获取羊水样本存在伦理和技术上的挑战，以及由于物种特异性差异，动物模型对人类的转化存在局限性，因此羊水生物学的研究一直不足。在了解其动态生理、组成和临床应用方面的最新进展，促进了产前护理，并促进了诊断和治疗策略的改进。随着研究继续阐明羊水的复杂性和进化功能，羊水在母胎医学中的作用日益得到认可，其改变临床实践的潜力只会变得更加明显。这篇综述的目的是强调羊水在塑造胎儿发育和治疗潜力中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.