Acute toxicity outcomes in Egyptian early-stage breast cancer: ultra-hypofractionated versus hypofractionated radiotherapy.

IF 2.1 Q3 ONCOLOGY

Journal of the Egyptian National Cancer Institute Pub Date : 2025-05-03 DOI:10.1186/s43046-025-00280-4

Ahmed Magdy, Emad Sadaka, Rasha Abd El Ghani, Taha Ahmed

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引用次数: 0

Abstract

Background: Comparison of acute adverse events (acute skin reaction, acute breast pain and lung toxicities) in early-stage breast cancer using 2 different fractionation schedules: ultra-hypofractionation versus hypofractionation radiotherapy.

Methods: Ninety-two patients were recruited and assessed using RTOG criteria for acute skin reactions at the end of radiotherapy, 1 month after, and 3 months after.

Results: There have been no statistically significant differences in acute skin adverse events in 1 month after WBI, there have been neither G3 acute skin toxicity nor G2 skin reactions as were in the fast trial, and milder than skin adverse events in the FAST-FORWARD trial. Acute breast pain at the end of radiotherapy has been statistically significantly lower in arm 1 vs arm 2. Acute breast pain at 1-month follow-up has been comparable between the study arms, with no statistically significant difference. At the 3-month follow-up, acute breast pain was similar in both arms. In all arms, no acute lung toxicities have been reported.

Conclusion: Acute adverse events have been comparable between ultra-hypofractionation and hypofractionation.

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埃及早期乳腺癌的急性毒性结果：超低分割与低分割放疗。

背景：比较两种不同分割方案：超低分割与低分割放疗对早期乳腺癌急性不良事件（急性皮肤反应、急性乳房疼痛和肺毒性）的影响。方法：招募92例患者，采用RTOG标准评估放疗结束、放疗后1个月、放疗后3个月的急性皮肤反应。结果：WBI后1个月急性皮肤不良事件无统计学差异，未出现快速组的G3急性皮肤毒性和G2皮肤不良反应，且较快进组的皮肤不良事件轻。放疗结束时的急性乳房疼痛在1组比2组有统计学意义上的显著降低。随访1个月的急性乳房疼痛在研究组之间具有可比性，无统计学意义差异。在3个月的随访中，两臂的急性乳房疼痛相似。在所有病例中，没有急性肺毒性的报道。结论：急性不良事件在超低分割和低分割之间具有可比性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Egyptian National Cancer Institute ONCOLOGY-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： As the official publication of the National Cancer Institute, Cairo University, the Journal of the Egyptian National Cancer Institute (JENCI) is an open access peer-reviewed journal that publishes on the latest innovations in oncology and thereby, providing academics and clinicians a leading research platform. JENCI welcomes submissions pertaining to all fields of basic, applied and clinical cancer research. Main topics of interest include: local and systemic anticancer therapy (with specific interest on applied cancer research from developing countries); experimental oncology; early cancer detection; randomized trials (including negatives ones); and key emerging fields of personalized medicine, such as molecular pathology, bioinformatics, and biotechnologies.