Role of Endophytic Fungi in the Biosynthesis of Metal Nanoparticles and Their Potential as Nanomedicines.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of Functional Biomaterials Pub Date : 2025-04-03 DOI:10.3390/jfb16040129

Hanadi Sawalha, Simon E Moulton, Andreas Winkel, Meike Stiesch, Bita Zaferanloo

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引用次数: 0

Abstract

Metal nanoparticles (MNPs) produced through biosynthesis approaches have shown favourable physical, chemical, and antimicrobial characteristics. The significance of biological agents in the synthesis of MNPs has been acknowledged as a promising alternative to conventional approaches such as physical and chemical methods, which are confronted with certain challenges. To meet these challenges, the use of endophytic fungi as nano-factories for the synthesis of MNPs has become increasingly popular worldwide in recent times. This review provides an overview of the synthesis of MNPs using endophytic fungi, the mechanisms involved, and their important biomedical applications. A special focus on different biomedical applications of MNPs mediated endophytic fungi involved their antibacterial, antifungal, antiviral, and anticancer applications and their potential as drug delivery agents. Furthermore, this review highlights the significance of the use of endophytic fungi for the green synthesis of MNPs and discusses the benefits, challenges, and prospects in this field.

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内生真菌在金属纳米颗粒生物合成中的作用及其作为纳米药物的潜力。

通过生物合成方法生产的金属纳米颗粒（MNPs）显示出良好的物理、化学和抗菌特性。生物制剂在MNPs合成中的重要性已被公认为是物理和化学方法等传统方法的有希望的替代方法，这些方法面临着一定的挑战。为了应对这些挑战，近年来，利用内生真菌作为纳米工厂合成MNPs已在世界范围内日益流行。本文综述了利用内生真菌合成MNPs的研究进展、机制及其重要的生物医学应用。特别关注MNPs介导的内生真菌的不同生物医学应用，包括它们的抗菌、抗真菌、抗病毒和抗癌应用以及它们作为药物递送剂的潜力。此外，本文强调了利用内生真菌绿色合成MNPs的意义，并讨论了该领域的优势、挑战和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.