Clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: A systematic review and meta-analysis.

Journal of advanced periodontology & implant dentistry Pub Date : 2025-01-20 eCollection Date: 2025-03-01 DOI:10.34172/japid.2025.002

Nisha Ashifa, Krishnan Viswanathan, Sivapragasam Srinivasan, Varsha K Pavithran, Shiva Shankar, Rajasekar Sundaram, Senthil Kumar, Divvi Anusha

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Abstract

Background: This study aimed to evaluate the clinical effect of aloe vera gel as an adjunct to scaling and root planing (SRP) on plaque index (PI), gingival index (GI), and probing pocket depth (PPD) in periodontitis treatment.

Methods: Randomized controlled trials (RCTs) were included, focusing on aloe vera gel as an adjunct to SRP in periodontitis patients. An extensive literature search was conducted across PubMed, PubMed Central, Scopus, OVID, Google Scholar, and Cochrane Library databases up to October 2024. The risk of bias was assessed using the Revised Cochrane Risk of Bias tool (ROB 2.0), and statistical analysis was performed using Review Manager 5.4.1.

Results: Fifteen RCTs were included in this systematic review, and separate meta-analyses were conducted for each outcome. For PI, the random effects model showed a mean difference (MD) of -0.23 (95% CI: -0.69, 0.23), favoring the experimental group (P=0.33). The fixed effects model for PI favored the control group (MD=0.12; P=0.20). For GI, the random effects model favored the experimental group (MD=-0.28, P=0.01), while the fixed effects model favored the control group (MD=0.17; P<0.001). For PPD, the random effects model favored the experimental group (MD=-0.45, P=0.009).

Conclusion: As an adjunct to SRP, aloe vera gel significantly improved PI, GI, and PPD in periodontitis patients.

Trial registration: PROSPERO ID: CRD42020201315.

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芦荟凝胶作为牙周炎患者机械清创辅助治疗的临床效果：一项系统综述和荟萃分析。

背景：本研究旨在评价芦荟凝胶辅助刮治和刨根（SRP）治疗牙周炎对菌斑指数（PI）、牙龈指数（GI）和探诊袋深度（PPD）的临床效果。方法：纳入随机对照试验（rct），重点研究芦荟凝胶作为牙周炎患者SRP的辅助治疗。在PubMed， PubMed Central, Scopus， OVID，谷歌Scholar和Cochrane Library数据库中进行了广泛的文献检索，直至2024年10月。采用修订Cochrane偏倚风险工具（ROB 2.0）评估偏倚风险，使用Review Manager 5.4.1进行统计分析。结果：本系统综述纳入了15项随机对照试验，并对每个结果进行了单独的荟萃分析。对于PI，随机效应模型显示平均差异（MD）为-0.23 (95% CI: -0.69, 0.23)，有利于实验组（P=0.33）。PI的固定效应模型对对照组有利(MD=0.12；P = 0.20)。对于GI，随机效应模型倾向于实验组（MD=-0.28， P=0.01），固定效应模型倾向于对照组(MD=0.17；页= 0.009)。结论：芦荟凝胶作为SRP的辅助治疗，可显著改善牙周炎患者的PI、GI和PPD。试验注册：PROSPERO ID: CRD42020201315。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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