Do genetic variants of the Y chromosome affect mortality from COVID-19.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Scandinavian Journal of Public Health Pub Date : 2025-07-01 Epub Date: 2025-04-14 DOI:10.1177/14034948251333236

Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Roald Omdal, Begoña Martínez Jarreta, Ángel Gómez Moreno, Ignacio De Blas, Geir Sverre Braut

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引用次数: 0

Abstract

Aims: During the early stages of the COVID-19 pandemic, significant differences in mortality patterns emerged based on sex and geographical regions. While we were studying on the heredity of variants of the Y chromosome, we observed that regional variations in mortality rates appeared to correlate with the geographical distribution of certain variants of the Y chromosome. This observation led us to propose that some genes on the Y chromosome, with an influence on immune responses, may represent a confounding factor in the observed geographical mortality differences.

Methods: In this analysis, we investigate the potential associations between COVID-19 morbidity and disease-specific mortality and specific Y chromosome variants. The study is based on publicly available pandemic data validated by state authorities or presented in scientific literature documented in PubMed and Medline.

Results: We find that Y chromosome haplogroups in different populations exhibit wave-like patterns corresponding with persistent global disparities in COVID-19-related mortality.

Conclusions: These findings warrant further research to uncover possible new pathophysiological mechanisms.

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Y染色体的遗传变异会影响COVID-19的死亡率吗？

目的：在COVID-19大流行的早期阶段，基于性别和地理区域的死亡模式出现了显著差异。当我们研究Y染色体变异的遗传时，我们观察到死亡率的区域差异似乎与Y染色体某些变异的地理分布有关。这一观察结果使我们提出，Y染色体上一些影响免疫反应的基因可能是观察到的地理死亡率差异的混淆因素。方法：在本分析中，我们调查了COVID-19发病率与疾病特异性死亡率和特异性Y染色体变异之间的潜在关联。该研究基于国家当局验证的公开可用的大流行数据，或在PubMed和Medline记录的科学文献中提出。结果：我们发现不同人群的Y染色体单倍群呈现波状模式，与covid -19相关死亡率的持续全球差异相对应。结论：这些发现值得进一步研究以揭示可能的新的病理生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.90%

发文量

135

审稿时长

4-8 weeks

期刊介绍： The Scandinavian Journal of Public Health is an international peer-reviewed journal which has a vision to: publish public health research of good quality; contribute to the conceptual and methodological development of public health; contribute to global health issues; contribute to news and overviews of public health developments and health policy developments in the Nordic countries; reflect the multidisciplinarity of public health.