Association between insulin resistance and multiple chronic diseases: a cross-sectional study from CHARLS.

IF 2.4 3区医学 Q3 ENVIRONMENTAL SCIENCES

Journal of Health, Population, and Nutrition Pub Date : 2025-05-09 DOI:10.1186/s41043-025-00878-3

Wen-Ze Jiang, Zhen-Liang Fan, Meng-Li Xu, En-Hui Qian, Ke-Da Lu

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引用次数: 0

Abstract

Background: Chronic disease is a global public health problem. This study aimed to explore the association between insulin resistance (IR)-related indices and various chronic diseases, and to evaluate the predictive capacity of IR-related indices for these diseases.

Methods: The data used in this study came from CHARLS. Binary logistic regression analysis and RCS were used to analyze the relationship between IR-related indices, including TyG, TyG-BMI, TyG-WHtR, METS-IR and eGDR, with nine chronic diseases. Subgroup analysis was performed to test the stability of the results. Finally, the predictive power of IR-related indices for chronic diseases was tested by ROC curve.

Results: A total of 8,177 participants were included in this study. The study found that elevated prevalence of multiple chronic diseases is positively associated with increases in TyG, TyG-BMI, TyG-WHtR, and METS-IR, and negatively associated with eGDR. ROC analysis revealed that IR-related indices had the best accuracy in predicting dyslipidemia compared to other diseases, with TyG being the best predictor.

Conclusions: IR-related indices were positively associated with the prevalence of multiple chronic diseases. The burden of chronic diseases can be reduced by improving IR in middle-aged and older people.

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胰岛素抵抗与多种慢性疾病之间的关系：CHARLS的横断面研究

背景：慢性病是一个全球性的公共卫生问题。本研究旨在探讨胰岛素抵抗（insulin resistance， IR）相关指标与各种慢性疾病的相关性，并评价IR相关指标对这些疾病的预测能力。方法：本研究资料来自CHARLS。采用二元logistic回归分析和RCS分析ir相关指标TyG、TyG- bmi、TyG- whtr、METS-IR和eGDR与9种慢性疾病的关系。进行亚组分析以检验结果的稳定性。最后，采用ROC曲线检验ir相关指标对慢性疾病的预测能力。结果：本研究共纳入8177名受试者。研究发现，多种慢性疾病患病率升高与TyG、TyG- bmi、TyG- whtr和METS-IR升高呈正相关，与eGDR呈负相关。ROC分析显示，与其他疾病相比，ir相关指标预测血脂异常的准确性最好，其中TyG是最好的预测指标。结论：ir相关指标与多种慢性疾病的患病率呈正相关。通过改善中老年人的IR，可以减轻慢性病的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Health, Population, and Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.