tRNA-Derived Fragments in Age-Related Diseases: A Systematic Review.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Kamilla Bakowska-Zywicka, Alicja Rzepczak, Kinga Plawgo, Daria Sobanska, Agata Tyczewska
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引用次数: 0

Abstract

Aging is a progressive weakening of numerous functions of organisms resulting in diminished abilities to safeguard against environmental damage and augment physiological harmony. It is not a disease in itself; however, it is a main cause of debilitating and life-threatening chronic aging-related diseases (ARDs). tRNA-derived fragments (tDRs) are stable forms of tRNAs of 14-35 nt in length that function as regulatory small-RNA molecules. Here we aimed to perform a systematic review of original articles on the involvement of tDRs in the etiology of ARDs: their identification and characterization. The systematic review was conducted according to the Cochrane Handbook guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Based on the eligibility criteria defined for the study, 21 original articles were included in this systematic review, covering 11 ARDs. The preferred research method used to study tDRs was high-throughput sequencing combined with RT-qPCR, and as a result, a number of tDRs were implicated in ARDs. Importantly, an in-depth analysis of the articles allowed us to identify several shortcomings: (i) the tDRs nomenclature varies between studies and articles, making it often difficult to precisely identify molecules differentiating in a given disease; (ii) the chosen tDRs have all been studied for a miRNA-like mechanism of action; however, tDRs also function in RNAi-independent ways, which need to be studied as well; (iii) to precisely identify tDRs, the sequencing techniques that overcome the issues of modifications harbored by tRNAs must be used.

年龄相关疾病中的trna衍生片段:系统综述。
衰老是生物体许多功能的逐渐减弱,导致抵御环境破坏和增强生理和谐的能力减弱。它本身并不是一种疾病;然而,它是使人衰弱和危及生命的慢性衰老相关疾病(ARDs)的主要原因。trna衍生片段(tdr)是长度为14- 35nt的trna的稳定形式,具有调节小rna分子的功能。在这里,我们的目的是对tdr在ARDs病因学中的参与的原始文章进行系统回顾:它们的识别和表征。系统评价按照Cochrane手册指南和系统评价和荟萃分析首选报告项目(PRISMA)声明进行。根据为研究定义的资格标准,本系统综述纳入了21篇原创文章,涵盖11例ARDs。研究tdr的首选研究方法是高通量测序与RT-qPCR相结合,因此,许多tdr与ARDs有关。重要的是,对文章的深入分析使我们能够确定几个缺点:(i) tdr的命名法在研究和文章之间有所不同,因此通常难以准确识别特定疾病的分子;(ii)已对所选的tdr进行了类似mirna的作用机制研究;然而,tdr也以与rnai无关的方式发挥作用,这也需要研究;(iii)为了精确识别tdr,必须使用能够克服trna修饰问题的测序技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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