Impact of bariatric surgery on serum C5a levels: A prospective study

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice Pub Date : 2025-05-01 DOI:10.1016/j.orcp.2025.04.005

Mariana D.S. Testa , Renato Nisihara , Alessandro F. Tonial , Paulo A. Nunes Nassif , Thelma Skare

引用次数: 0

Abstract

C5a, a key complement pathway component, is produced in adipose tissue and promotes inflammation linked to atherosclerosis. It also influences lipid and glucose metabolism, suggesting a role in obesity-related dysfunction. This study measured by ELISA serum C5a levels in individuals with obesity before and after Roux-en-Y gastric bypass. Pre-surgery, the median C5a level was 12.0 ng/mL (IQR: 7.0–18.0); post-surgery, it dropped to 6.3 ng/mL (IQR: 4.4–8.9; p = 0.0002). However, no significant correlations were found between C5a changes and lipid or glycemic profiles.

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减肥手术对血清C5a水平的影响：一项前瞻性研究

C5a是一种关键的补体途径成分，在脂肪组织中产生，并促进与动脉粥样硬化相关的炎症。它还影响脂质和葡萄糖代谢，表明在肥胖相关功能障碍中起作用。本研究采用ELISA法测定肥胖患者Roux-en-Y胃旁路术前后血清C5a水平。术前C5a水平中位数为12.0 ng/mL (IQR: 7.0 ~ 18.0)；术后降至6.3 ng/mL (IQR: 4.4-8.9； = 0.0002页)。然而，没有发现C5a变化与血脂或血糖谱之间的显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity research & clinical practice 医学-内分泌学与代谢

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： The aim of Obesity Research & Clinical Practice (ORCP) is to publish high quality clinical and basic research relating to the epidemiology, mechanism, complications and treatment of obesity and the complication of obesity. Studies relating to the Asia Oceania region are particularly welcome, given the increasing burden of obesity in Asia Pacific, compounded by specific regional population-based and genetic issues, and the devastating personal and economic consequences. The journal aims to expose health care practitioners, clinical researchers, basic scientists, epidemiologists, and public health officials in the region to all areas of obesity research and practice. In addition to original research the ORCP publishes reviews, patient reports, short communications, and letters to the editor (including comments on published papers). The proceedings and abstracts of the Annual Meeting of the Asia Oceania Association for the Study of Obesity is published as a supplement each year.