Correlation of the adhesion of the elements of atheroma and the causes of thrombosis.

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis Pub Date : 2025-05-07 DOI:10.1016/j.arteri.2025.500801

Irving Mauricio Lecona Licona, José María Rodríguez Lelis, Joaquín Pérez Ortega, José Alfredo Rodríguez Ramírez

{"title":"Correlation of the adhesion of the elements of atheroma and the causes of thrombosis.","authors":"Irving Mauricio Lecona Licona, José María Rodríguez Lelis, Joaquín Pérez Ortega, José Alfredo Rodríguez Ramírez","doi":"10.1016/j.arteri.2025.500801","DOIUrl":null,"url":null,"abstract":"Introduction: Ischemic diseases are the second leading cause of death in Mexico and account for over 30% of deaths worldwide. Atherosclerosis, in particular, obstructs arteries and impairs blood circulation, contributing to increased mortality and reduced quality of life. Objective In this study, adhesion energies and their influence on the structural arrangement of an atheroma were determined.Methodology: Adhesion energies were measured for each main component of the atheroma, including arteries and plaque components such as cholesterol, calcium, collagen, glucose, and elastin. The relationship between adhesion and atheroma formation is demonstrated, highlighting the significant interaction of adhesion energies between fibrinogen and cholesterol. Numerical results showed that fibrinogen and cholesterol have the highest adhesion energy, followed by collagen-glucose and cholesterol-elastin combinations.Results: Additionally, interactions with the highest adhesion energy, such as Fib-Fib with an energy value of 9.60x10-5J/m2, CML-GB with a value of 2.76x10-9J/m2, along with LDL-LDL with an adhesion value of 6.35x10-5J/m2 and Elas-LDL with a J value of 3.40x10-5J/m2, influence the atheroma structure formation.Conclusions: These results demonstrate the association between adhesion energy in forming an atheroma that obstructs arteries, reduces blood flow, and the pathology of thrombus formation.","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500801"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinica e Investigacion en Arteriosclerosis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.arteri.2025.500801","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Ischemic diseases are the second leading cause of death in Mexico and account for over 30% of deaths worldwide. Atherosclerosis, in particular, obstructs arteries and impairs blood circulation, contributing to increased mortality and reduced quality of life. Objective In this study, adhesion energies and their influence on the structural arrangement of an atheroma were determined.

Methodology: Adhesion energies were measured for each main component of the atheroma, including arteries and plaque components such as cholesterol, calcium, collagen, glucose, and elastin. The relationship between adhesion and atheroma formation is demonstrated, highlighting the significant interaction of adhesion energies between fibrinogen and cholesterol. Numerical results showed that fibrinogen and cholesterol have the highest adhesion energy, followed by collagen-glucose and cholesterol-elastin combinations.

Results: Additionally, interactions with the highest adhesion energy, such as Fib-Fib with an energy value of 9.60x10^-5J/m², CML-GB with a value of 2.76x10^-9J/m², along with LDL-LDL with an adhesion value of 6.35x10^-5J/m² and Elas-LDL with a J value of 3.40x10^-5J/m², influence the atheroma structure formation.

Conclusions: These results demonstrate the association between adhesion energy in forming an atheroma that obstructs arteries, reduces blood flow, and the pathology of thrombus formation.

查看原文本刊更多论文

动脉粥样硬化成分的粘连与血栓形成的关系。

简介：缺血性疾病是墨西哥的第二大死因，占全世界死亡人数的30%以上。动脉粥样硬化尤其会阻塞动脉，损害血液循环，导致死亡率上升和生活质量下降。目的研究动脉粥样硬化黏附能及其对动脉粥样硬化结构排列的影响。方法：测量动脉粥样硬化各主要成分的粘附能，包括动脉和斑块成分，如胆固醇、钙、胶原蛋白、葡萄糖和弹性蛋白。粘连和动脉粥样硬化形成之间的关系被证明，强调纤维蛋白原和胆固醇之间的粘连能量的显著相互作用。数值结果表明，纤维蛋白原和胆固醇具有最高的粘附能，其次是胶原-葡萄糖和胆固醇-弹性蛋白组合。结果：黏附能最高的Fib-Fib能值为9.60x10-5J/m2， CML-GB能值为2.76x10-9J/m2， LDL-LDL黏附能值为6.35x10-5J/m2， elasl - ldl黏附能值为3.40x10-5J/m2，相互作用影响动脉粥样硬化结构形成。结论：这些结果表明，在形成阻塞动脉、减少血流量的动脉粥样硬化过程中，粘附能量与血栓形成的病理之间存在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinica e Investigacion en Arteriosclerosis PERIPHERAL VASCULAR DISEASE-

CiteScore

3.20

自引率

6.20%

发文量

审稿时长

40 days

期刊介绍： La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.