[Biosimilars of ranibizumab in retinal diseases: new possibilities in ophthalmology].

Q3 Medicine
A A Voskresenskaya, M B Sarkizova, N S Khodzhaev, D A Kudlay, S A Kakunina, A Yu Borozinets, N A Pozdeyeva
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引用次数: 0

Abstract

The development of biological therapeutic agents has provided new opportunities for treating neovascular age-related macular degeneration (nAMD) using humanized monoclonal antibodies (mAbs) targeting vascular endothelial growth factor A (VEGF-A). The emergence of biosimilars of anti-VEGF agents can significantly improve treatment accessibility and its effectiveness by increasing patient adherence. The development of biosimilars involves comparative studies with the original drug to establish equivalence in physicochemical and biological properties, efficacy, and safety. Biosimilar development programs include extensive analytical and preclinical studies to compare structural and functional components with the original bioproduct, and clinical trials are conducted to prove bioequivalence and therapeutic equivalence. The process of development and registration of the biosimilars is strictly regulated and has no significant differences in Russia, the EU and the US. Currently, more than 10 biosimilars of ranibizumab have been approved worldwide, in Russia it is the drug Laxolan (AO GENERIUM). The introduction of a domestic biosimilar of ranibizumab into clinical practice allows reduction of the costs of retinal disease treatment while maintaining the efficacy and safety of antiangiogenic therapy.

[雷尼单抗治疗视网膜疾病的生物仿制药:眼科的新可能性]。
生物治疗剂的发展为利用靶向血管内皮生长因子A (VEGF-A)的人源化单克隆抗体(mab)治疗新生血管性年龄相关性黄斑变性(nAMD)提供了新的机遇。抗vegf药物的生物仿制药的出现可以通过增加患者的依从性来显著提高治疗的可及性和有效性。生物仿制药的开发涉及与原药的比较研究,以建立在物理化学和生物特性,功效和安全性方面的等效性。生物仿制药开发计划包括广泛的分析和临床前研究,以比较结构和功能成分与原始生物制品,并进行临床试验以证明生物等效性和治疗等效性。生物仿制药的开发和注册过程受到严格监管,在俄罗斯、欧盟和美国没有显著差异。目前,全世界有10多个雷尼单抗的生物仿制药被批准,在俄罗斯是药物Laxolan (AO GENERIUM)。将雷尼单抗的国内生物仿制药引入临床实践,可以降低视网膜疾病治疗的成本,同时保持抗血管生成治疗的有效性和安全性。
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来源期刊
Vestnik oftalmologii
Vestnik oftalmologii Medicine-Ophthalmology
CiteScore
0.80
自引率
0.00%
发文量
129
期刊介绍: The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.
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