Body composition metrics as a determinant of trastuzumab deruxtecan related toxicity and response.

IF 7.6 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2025-04-25 DOI:10.1038/s41523-025-00754-7

Shiran Yaacobi Peretz, Rivka Kessner, Yael Bar, Amir Sonnenblick, Shir Lerner, Ariella Deutsch-Lukatsky, Karteek Popuri, Mirza Faisal Beg, Shlomit Strulov Shachar

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Abstract

Body composition is an important predictor in cancer patients, with skeletal muscle loss and high adiposity associated with poorer prognosis. This study evaluated how body composition affects treatment efficacy in 48 women with metastatic breast cancer receiving trastuzumab deruxtecan. Using computed tomography, skeletal muscle, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were assessed within 60 days before initiating treatment. High SAT and VAT areas were significantly associated with a higher likelihood of dose reductions (Odds Ratio [OR] = 5.34, p = .032 and OR = 5.52, p = 0.032, respectively). Higher SAT areas correlated with a lower objective response rate (OR = 0.22, p = 0.047). Medium SAT and low/medium VAT densities increased the risk of dose reductions. A body mass index over 25 kg/m² was linked to higher dose reductions (OR = 4.97, p = 0.016). These findings emphasize the need for personalized treatment strategies based on body composition.

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体成分指标作为曲妥珠单抗德鲁德替康相关毒性和反应的决定因素。

身体成分是癌症患者的重要预测因子，骨骼肌损失和高脂肪与预后不良相关。本研究评估了48例接受曲妥珠单抗德鲁德康治疗的转移性乳腺癌患者的身体成分如何影响治疗效果。在开始治疗前60天内，使用计算机断层扫描，评估骨骼肌、内脏脂肪组织（VAT）和皮下脂肪组织（SAT）。高SAT和VAT区域与剂量减少的可能性显著相关(优势比[OR] = 5.34, p =。OR = 5.52, p = 0.032)。较高的SAT区域与较低的客观反应率相关（OR = 0.22, p = 0.047）。中等SAT和低/中等VAT密度增加了剂量减少的风险。体重指数超过25 kg/m2与较高的剂量减少有关（OR = 4.97, p = 0.016）。这些发现强调了基于身体成分的个性化治疗策略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.