HEART FAILURE IN PATIENTS WITH SARCOPENIA: SYSTEMATIC REVIEW AND META-ANALYSIS.

IF 2.8 Q3 GERIATRICS & GERONTOLOGY

Annals of Geriatric Medicine and Research Pub Date : 2025-04-10 DOI:10.4235/agmr.24.0186

Pedro Ivo Carmo Campos, Marcus Vinicius Bolivar Malachias, Amanda Aparecida Oliveira Leopoldino, Juliano Bergamaschine Mata Diz

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Abstract

Introduction: The prevalence of sarcopenia and heart failure (HF) is estimated to be between 8% - 34% and 3% - 11.8%, respectively. The prevalence of HF in patients with sarcopenia and the prognosis of this association remain unclear.

Methods:  A systematic review was conducted across MEDLINE/PubMed, Embase, CENTRAL, Scielo, and CINAHL databases, with manual searches in Google Scholar and grey literature. Meta-analysis was performed on the gathered results to assess the prevalence of HF in patients with sarcopenia, estimate phenotypes related to left ventricular ejection fraction (LVEF), and evaluate the associated mortality risk.

Results: Out of 7.080 studies, 16 were selected. In patients with sarcopenia HF prevalence was 32% (95% CI 0.07-0.61, p<0.001, I²=100%). Patients with both conditions showed 45.9% (95% CI 0.34 - 0.58, p<0.001, I² 90.69%) with reduced LVEF, 10.3% (95% CI 0.00 - 0.29, p<0.001, I² 99%) with mildly reduced LVEF, and 29.1% (95% CI 0.14 - 0.45, p<0.001, I² 99%) having preserved LVEF.

Conclusion: HF is highly prevalent in patients with sarcopenia and increases mortality risk.

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肌肉减少症患者的心力衰竭：系统回顾和荟萃分析。

肌肉减少症和心力衰竭（HF）的患病率估计分别在8% - 34%和3% - 11.8%之间。肌少症患者的心衰患病率及其预后尚不清楚。方法： 对MEDLINE/PubMed、Embase、CENTRAL、Scielo和CINAHL数据库进行系统评价，手动检索谷歌Scholar和灰色文献。对收集到的结果进行荟萃分析，以评估肌肉减少症患者心力衰竭的患病率，估计与左心室射血分数（LVEF）相关的表型，并评估相关的死亡风险。结果：在7.080项研究中，选择了16项。在肌少症患者中HF患病率为32% （95% CI 0.07-0.61）。结论：HF在肌少症患者中高度流行，并增加死亡风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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