Psoas Muscle Volume Is a Useful Predictor of Postoperative Outcome in Elderly Patients With Non-Small Cell Lung Cancer.

IF 2.3 3区医学 Q3 ONCOLOGY

Thoracic Cancer Pub Date : 2025-04-01 DOI:10.1111/1759-7714.70077

Shinogu Takashima, Tsubasa Matsuo, Shoji Kuriyama, Hidenobu Iwai, Haruka Suzuki, Tatsuki Fujibayashi, Sumire Shibano, Yusuke Sato, Kyoko Nomura, Yoshihiro Minamiya, Kazuhiro Imai

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引用次数: 0

Abstract

Background: As the population ages, the number of elderly lung cancer patients has been increasing. While surgery is the best treatment for resectable lung cancer, elderly patients often have multiple comorbidities, making accurate preoperative risk assessment crucial when formulating an appropriate treatment plan. This study aims to explore how psoas muscle volume relates to postoperative outcomes in elderly lung cancer patients.

Methods: This single-center, retrospective study included 344 elderly (≥ 75) patients who underwent complete surgical resection for non-small cell cancer between 2010 and 2023. The psoas muscle volume index (PVI, cm³/m³) was measured using a 3-dimensional imaging workstation based on preoperative computed tomography images and grouped based on the median value for each gender. Postoperative complications and survival rates were then compared between the groups.

Results: The median PVI was 60.5 cm³/m³ for males and 47.7 cm³/m³ for females. The PVI-high group had significantly fewer complications (15.6%) than the PVI-low group (37.1%) (p < 0.001). The 5-year overall survival (OS) rate was higher in the PVI-high group (80.5%) than in the PVI-low group (66.7%) (p = 0.01). Multivariate analyses showed that PVI-high was an independent predictor of lower complication risk (odds ratio 0.28, p < 0.001) and an independent factor that improved OS (hazard ratio 0.60, p = 0.042).

Conclusions: PVI in elderly lung cancer patients is associated with postoperative complications and survival.

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腰肌体积是老年非小细胞肺癌患者术后预后的有效预测指标。

背景：随着人口老龄化，老年肺癌患者不断增加。虽然手术是可切除肺癌的最佳治疗方法，但老年患者往往有多种合并症，因此在制定适当的治疗计划时，准确的术前风险评估至关重要。本研究旨在探讨腰肌体积与老年肺癌患者术后预后的关系。方法：这项单中心、回顾性研究纳入了2010年至2023年间接受非小细胞癌完全手术切除的344例老年（≥75）患者。腰大肌体积指数（PVI, cm3/m3）采用基于术前计算机断层扫描图像的三维成像工作站测量，并根据性别中位数分组。比较两组患者术后并发症及生存率。结果：男性PVI中位数为60.5 cm3/m3，女性为47.7 cm3/m3。PVI高组并发症发生率（15.6%）明显低于PVI低组（37.1%）(p)。结论：老年肺癌患者PVI与术后并发症及生存率相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM

CiteScore

5.20

自引率

3.40%

发文量

439

审稿时长

2 months

期刊介绍： Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.