Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2025-03-29 eCollection Date: 2025-01-01 DOI:10.4103/jrms.jrms_542_24

Fariborz Khorvash, Elham Bani, Rasool Soltani, Majid Rezvani, Mohammad Saadatnia, Noushin Maktoobian, Mohsen Kheradmand

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引用次数: 0

Abstract

Background: Traumatic brain injury (TBI) can result in different complications. Posttraumatic headache (PTH) is a disabling complication of TBI. We investigated the therapeutic effect of memantine on patients with PTH.

Materials and methods: This randomized and double-blinded clinical trial was performed in 2020 in a hospital on 90 patients with head trauma. Patients were divided into two groups. The active group received 5 mg memantine tablet for 2 weeks followed by 10 mg tablet daily for up to 6 months. The control arm received identical placebo tablets. Patients were evaluated at 3 months and 6 months. Headache severity was measured with a Visual Analog Scale for Pain. Headache frequency (per week) and duration were also recorded.

Results: After 3 months, the patients in the memantine group had significantly lower headache severity (P = 001) and frequency (P = 0.008) in comparison to baseline of the study. However, in the placebo group, there was only significant reduction in the headache duration (P = 0.001), and there was no significant reduction in headache intensity and frequency. After 6 months, there was a significant reduction in headache intensity and duration in both groups (P < 0.05), but only in the memantine group, headache frequency was significantly reduced (P < 0.001). Finally, patients in the memantine group had less headache intensity, frequency, and duration after 6 months of taking memantin than the placebo group.(P < 0.05 for all).

Conclusion: The administration of memantine for 6 months could significantly lower the severity, duration, and frequency of PTHs.

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美金刚治疗创伤后头痛的疗效：一项随机双盲临床试验。

背景：创伤性脑损伤（TBI）可导致不同的并发症。创伤后头痛（PTH）是创伤性脑损伤的致残性并发症。我们观察美金刚对甲状旁腺激素的治疗效果。材料与方法：本研究于2020年在某医院对90例头部外伤患者进行了随机双盲临床试验。患者分为两组。活性组给予美金刚片5mg，连续2周，随后每日10mg，连续6个月。对照组服用相同的安慰剂片。分别在3个月和6个月时对患者进行评估。用疼痛视觉模拟量表测量头痛严重程度。同时记录头痛频率（每周）和持续时间。结果：3个月后，与研究基线相比，美金刚组患者头痛严重程度（P = 001）和频率（P = 0.008）明显降低。然而，在安慰剂组中，只有头痛持续时间显著减少（P = 0.001），头痛强度和频率没有显著减少。6个月后，两组患者头痛强度和持续时间均显著降低（P < 0.05），但只有美金刚组患者头痛频率显著降低（P < 0.001）。最后，美金刚组患者在服用美金刚6个月后头痛强度、频率和持续时间均低于安慰剂组。（P < 0.05）。结论：应用美金刚6个月可显著降低甲状旁突的严重程度、持续时间和发生频率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.