Deciphering the effective substances of mangrove plant Acanthus ilicifolius Linn. against liver injury.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-09 DOI:10.1080/14786419.2025.2503012

Qing Zhao, Shu-Yue Song, Han Fang, Yao-Yao Zheng, Meng-Qi Zhang, Xia Ren, Ya-Hui Zhang, Xiu-Mei Fu, Xin Li, Chang-Yun Wang

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Abstract

The mangrove plant Acanthus ilicifolius Linn. has been recorded to treat liver injury diseases, but its active ingredients are unclear. In the present study, chemical compounds in the ethanol extract of A. ilicifolius were isolated, and their anti-liver injury, anti-inflammatory and anti-oxidant activities were evaluated to decipher the effective substances. In total, 42 compounds (1-42) were obtained, including two new naphthalene compounds (1-2). Moreover, the anti-liver injury, anti-inflammatory and anti-oxidant activities of compounds were evaluated. In CCl₄-induced HepG2 cellular model, compound 33 showed significant anti-liver injury activity at 50, 25, 12.5 and 6.25 μM, while 1, 9, 13-16, 33 showed significant activity at 50 and 25 μM. Overall, naphthalenes (1-2), phenylethanoid glycosides (12-16), alkaloid (3), flavonoid (9) and lignin (33) could be the main effective substances in A. ilicifolius against liver injury.

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红树林植物刺槐有效物质的解译。防止肝损伤。

红树植物刺槐。已被记载用于治疗肝损伤性疾病，但其有效成分尚不清楚。本研究对黄连乙醇提取物中的化学成分进行了分离，并对其抗肝损伤、抗炎和抗氧化活性进行了评价，以确定其有效成分。共得到42个化合物（1-42），包括两个新的萘化合物（1-2）。并对化合物的抗肝损伤、抗炎和抗氧化活性进行了评价。在ccl4诱导的HepG2细胞模型中，化合物33在50、25、12.5和6.25 μM具有显著的抗肝损伤活性，而化合物1、9、13-16、33在50和25 μM具有显著的抗肝损伤活性。综上所述，萘（1-2）、苯乙醇苷（12-16）、生物碱(3)、类黄酮(9)和木质素（33）可能是黄芪抗肝损伤的主要有效物质。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.