Increase in new-onset type 1 diabetes diagnoses among Brazilian children and adolescents during the COVID-19 pandemic.

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria Pub Date : 2025-05-29 DOI:10.1016/j.jped.2025.04.001

Renata Szundy Berardo, Melanie Rodacki, Bruna S Pugliese, Fernanda Roisman, Juliane Rocha, Daniel Gilban, Bianca Balassiano, Cristine Barboza Beltrão, Isla Aguiar Paiva, Juliana Veiga Moreira, Jorge Luescher, Ludmila Campos, Isabella Coutinho, Isabel Rey Madeira, Alessandra S M F da Costa, Lucianne R M Tannus, Nádia C P Rodrigues, Lenita Zajdenverg

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引用次数: 0

Abstract

Objective: This study aimed to determine if there was a rise in new T1DM cases in children during the pandemic in a large metropolitan area in Brazil.

Methods: The authors conducted a cross-sectional study at five public tertiary care centers that specialize in diabetes in children, comparing all new T1DM cases (ages 0.5-18y) diagnosed from March 2020 to December 2021 (pandemic period, PP) with those from March 2018 to December 2019 (historical period, HP).

Results: There were 167 new cases in the PP compared to 99 in the HP, reflecting a 68.7 % rise, with a notable peak observed in the third quarter of 2020 (p = 0.006). The average age of diagnosis was 8.4 ± 4.2 years in the PP and 7.5 ± 3.6 years in the HP, with no significant difference (p = 0.06). The gender distribution, BMI Z scores, and duration of diabetes symptoms before diagnosis were similar. The incidence of diabetic ketoacidosis (DKA) at onset was elevated but did not increase during the pandemic (62.6 % historical vs. 59.3 % pandemic period). During the PP, 24 % of patients reported symptoms of SARS-CoV-2 infection before the diagnosis of T1DM or at admission, and 13 % (7/53) of tested patients were positive for SARS-CoV-2.

Conclusions: The present findings indicate a significant rise in new T1DM cases among children during the COVID-19 pandemic compared to prior years, without differences in DKA at onset.

查看原文本刊更多论文

在2019冠状病毒病大流行期间，巴西儿童和青少年新发1型糖尿病诊断率上升。

目的：本研究旨在确定大流行期间巴西大城市地区儿童T1DM新病例是否有所增加。方法：作者在五家专门治疗儿童糖尿病的公立三级医疗中心进行了一项横断面研究，比较了2020年3月至2021年12月（大流行期，PP）和2018年3月至2019年12月（历史期，HP）诊断的所有新发T1DM病例（0.5-18岁）。结果：PP新增病例167例，HP新增病例99例，增幅为68.7% %，并在2020年第三季度达到显著峰值（p = 0.006）。PP患者的平均诊断年龄为8.4 ± 4.2岁，HP患者的平均诊断年龄为7.5 ± 3.6岁，差异无统计学意义（p = 0.06）。性别分布、BMI Z评分和诊断前糖尿病症状持续时间相似。发病时糖尿病酮症酸中毒（DKA）的发生率升高，但在大流行期间没有增加（历史62.6 % vs大流行期间59.3 %）。在PP期间，24 %的患者在T1DM诊断前或入院时报告了SARS-CoV-2感染症状，13 %（7/53）的检测患者呈SARS-CoV-2阳性。结论：目前的研究结果表明，与前几年相比，COVID-19大流行期间儿童中新发T1DM病例显著增加，但发病时DKA没有差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal de pediatria 医学-小儿科

CiteScore

5.60

自引率

3.00%

发文量

审稿时长

43 days

期刊介绍： Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.