North America Laboratory Survey Data for Drug Testing in Drug Impaired Driving and Traffic Fatality Investigations.

IF 2.6 3区 医学 Q3 CHEMISTRY, ANALYTICAL
Amanda L D'Orazio, Amanda L A Mohr, Ayako Chan-Hosokawa, Curt Harper, Marilyn A Huestis, Sarah Kerrigan, Jennifer F Limoges, Amy K Miles, Colleen E Scarneo, Karen S Scott, Barry K Logan
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Abstract

In 2004, the National Safety Council's Alcohol, Drugs and Impairment Division (NSC-ADID) set out to provide guidance for the standardization of laboratory testing practices in driving under the influence of drugs (DUID) and fatal motor vehicle crash investigations after identifying a lack of consistency in testing practices in this type of casework. A survey about laboratory testing practices, scopes of testing, and cutoffs was created using SurveyMonkey®, an online survey instrument, and sent to laboratories throughout the United States and Canada. Based on analysis of survey results and discussion, the first set of recommendations was published in 2007 with recommended scope and cutoffs for drug screening and confirmation in blood and urine. Subsequent surveys were sent to laboratories in 2012, 2016, and 2020, followed by updates to the recommendations published in 2013, 2017, and 2021. This publication highlights the 2024 survey results in addition to trends in drug testing practices and drug use positivity. With each survey year, data exhibited a shift of laboratories using newer and more sensitive technology such as Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) for screening and confirmation. Overall, data show that laboratories are willing to implement changes to be in compliance with the recommendations; however, challenges with instrument capacity and technology, lack of staffing, training, laboratory space constraints, and time associated with method development and validation hinder compliance with all of the recommendations. While compliance increased, 51% of laboratories reported using the practice of stop-limit testing, an administrative decision to stop testing if a blood alcohol concentration (BAC) result is at or above a certain concentration, which further hinders the understanding of the drug impaired driving problem. THC and/or metabolites remained the most prevalent drug reported by laboratories, followed by stimulants.

北美实验室调查数据药物测试在药物受损驾驶和交通事故调查。
2004年,国家安全委员会的酒精、毒品和损害司(NSC-ADID)在确定这类案件的测试做法缺乏一致性之后,着手为药物影响下驾驶(DUID)和致命机动车辆碰撞调查的实验室测试做法标准化提供指导。使用在线调查工具SurveyMonkey®创建了一份关于实验室测试实践、测试范围和截止时间的调查,并将其发送到美国和加拿大的实验室。根据对调查结果的分析和讨论,2007年发表了第一套建议,其中建议了血液和尿液中药物筛选和确认的范围和截止时间。随后于2012年、2016年和2020年向实验室发送了调查,随后对2013年、2017年和2021年发布的建议进行了更新。本出版物强调了2024年的调查结果,以及药物检测实践和药物使用阳性的趋势。在每一年的调查中,数据显示实验室使用更新和更灵敏的技术,如液相色谱-高分辨率质谱(LC-HRMS)进行筛选和确认。总体而言,数据显示,实验室愿意实施改变以符合建议;然而,仪器能力和技术方面的挑战、人员配备的缺乏、培训、实验室空间的限制以及与方法开发和验证相关的时间阻碍了所有建议的遵守。虽然遵守情况有所增加,但51%的实验室报告使用停止限制测试的做法,即如果血液酒精浓度(BAC)结果达到或高于某一浓度,则行政决定停止测试,这进一步阻碍了对药物受损驾驶问题的理解。四氢大麻酚和/或代谢物仍然是实验室报告的最普遍的药物,其次是兴奋剂。
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来源期刊
CiteScore
5.10
自引率
20.00%
发文量
92
审稿时长
6-12 weeks
期刊介绍: The Journal of Analytical Toxicology (JAT) is an international toxicology journal devoted to the timely dissemination of scientific communications concerning potentially toxic substances and drug identification, isolation, and quantitation. Since its inception in 1977, the Journal of Analytical Toxicology has striven to present state-of-the-art techniques used in toxicology labs. The peer-review process provided by the distinguished members of the Editorial Advisory Board ensures the high-quality and integrity of articles published in the Journal of Analytical Toxicology. Timely presentation of the latest toxicology developments is ensured through Technical Notes, Case Reports, and Letters to the Editor.
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