Fetal and Neonatal Deaths Resulting from Chikungunya Virus Infection During Pregnancy: A Case Series.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-04-05 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S506873
Ana Cristina Pedrosa Do Monte, Heloisa Ramos Lacerda
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引用次数: 0

Abstract

Purpose: We report maternal outcomes, fetal and neonatal deaths resulting from chikungunya virus (CHIKV) infection during pregnancy, addressing clinical manifestations, complications and laboratory changes.

Patients and methods: This case series included four pregnant women infected with the chikungunya virus during gestation, three fetal deaths, and two neonatal deaths confirmed as resulting from maternal-fetal transmission, during an epidemic in 2015 and 2016, in the state of Pernambuco, Northeastern Brazil. Laboratory and clinical-epidemiological criteria were applied to confirm the infection.

Results: All the pregnant women were symptomatic with an onset of symptoms from the first trimester of pregnancy until 4 days after birth, with the infection confirmed by laboratory and clinical-epidemiological criteria. Among the fetal deaths, changes in the brain were the most prominent (softening and autolysis). In the neonatal deaths, there were signs of acute suffering, and low Apgar, in addition to the manifestation of severe disease with skin hyperpigmentation, limb edema, and encephalitis.

Conclusion: We demonstrate the rare, although possible, occurrence of fetal death due to maternal CHIKV infection at any stage of pregnancy, as well as the risk of vertical transmission during birth, resulting in neonatal mortality. We would suggest that during epidemics this diagnosis should be considered in fetal and neonatal deaths of mothers with symptoms suggestive of chikungunya.

妊娠期感染基孔肯雅病毒导致的胎儿和新生儿死亡:一个病例系列。
目的:我们报告妊娠期间基孔肯雅病毒(CHIKV)感染导致的孕产妇结局、胎儿和新生儿死亡,解决临床表现、并发症和实验室变化。患者和方法:该病例系列包括2015年和2016年巴西东北部伯南布哥州流行期间4名妊娠期感染基孔肯雅病毒的孕妇,3例胎儿死亡和2例新生儿死亡,证实是由母胎传播造成的。采用实验室和临床流行病学标准确认感染。结果:所有孕妇均有症状,从妊娠早期至出生后4 d出现症状,符合实验室和临床流行病学标准。在胎儿死亡中,大脑的变化最为突出(软化和自溶)。在新生儿死亡中,除了表现为皮肤色素沉着、肢体水肿和脑炎等严重疾病外,还有急性痛苦和低Apgar的迹象。结论:我们证明,在妊娠的任何阶段,由于母体感染千伏病毒而导致胎儿死亡的发生虽然可能,但罕见,以及分娩时垂直传播的风险,导致新生儿死亡。我们建议,在流行期间,对有基孔肯雅热症状的母亲的胎儿和新生儿死亡应考虑这一诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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